Targeting HSP70 for Cancer Therapy

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Targeting HSP70 for Cancer Therapy Lorenzo Galluzzi, Fabrizio Giordanetto, Guido Kroemer Molecular Cell Volume 36, Issue 2, Pages 176-177 (October 2009) DOI: 10.1016/j.molcel.2009.10.003 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 Theoretical Interaction between PES and HSP70 The HSP70 C-terminal domain model (gray) was built by homology to the Escherichia coli DnaK template. PES (green) was then exhaustively docked to potential binding sites, and solutions were ranked based on predicted interaction energies and visual inspection. Interacting amino acids (from left to right, I427, T429, and A404) are depicted in pink. Scale bar, 10 Å. (A) Ribbon diagram of the C-terminal domain of HSP70 bound by PES. (B) Space-filling model of the C-terminal domain of HSP70 bound by PES. Molecular Cell 2009 36, 176-177DOI: (10.1016/j.molcel.2009.10.003) Copyright © 2009 Elsevier Inc. Terms and Conditions