New Insights Into the Cell Lineage of Pancreatic Ductal Adenocarcinoma: Evidence for Tumor Stem Cells in Premalignant Lesions? Janel L. Kopp, Maike Sander

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New Insights Into the Cell Lineage of Pancreatic Ductal Adenocarcinoma: Evidence for Tumor Stem Cells in Premalignant Lesions? Janel L. Kopp, Maike Sander Gastroenterology Volume 146, Issue 1, Pages 24-26 (January 2014) DOI: 10.1053/j.gastro.2013.11.023 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 Proposed lineage model for pancreatic ductal adenocarcinoma. Expression of oncogenic Kras transforms acinar cells into pancreatic intraepithelial neoplasia (PanIN) with characteristics of pancreatobiliary epithelium, including the presence of mucin-producing cells and rare Dclk1HIAcTubHI tuft cells (green). Dclk1HIAcTubHI cells isolated from premalignant PanIN lesions are clonogenic. Dclk1HIAcTubHI cells are maintained in invasive pancreatic ductal adenocarcinoma, where they function as cancer stem cells. The shared presence of clonogenic Dclk1HIAcTubHI cells at early and late stages of the disease suggests a possible lineage relationship and points to Dclk1HIAcTubHI cells in premalignant lesions as precursors for cancer stem cells. Gastroenterology 2014 146, 24-26DOI: (10.1053/j.gastro.2013.11.023) Copyright © 2014 AGA Institute Terms and Conditions