Obesity accompanied by increased triacylglyceride deposits in InsP3R mutants leads to starvation resistance. Obesity accompanied by increased triacylglyceride.

Slides:

Advertisements

Similar presentations

Diet modification and metformin have a beneficial effect in a fly model of obesity and mucormycosis Fazal Shirazi, PhD.

Advertisements

SESN2 expression in lungs from healthy donors, habitual smokers without COPD and individuals with late-stage COPD. (A) Representative western blots of.

Drosophila insulin release is triggered by adipose Stunted ligand to brain Methuselah receptor by Renald Delanoue, Eleonora Meschi, Neha Agrawal, Alessandra.

A Leptin Analog Locally Produced in the Brain Acts via a Conserved Neural Circuit to Modulate Obesity-Linked Behaviors in Drosophila Jennifer Beshel,

Matthew H. Sieber, Carl S. Thummel Cell Metabolism

Volume 23, Issue 1, Pages (January 2016)

Morphological alterations in pancreatic islets demonstrate a compensatory response to HFHC diet and STZ-induced β-cell loss. Morphological alterations.

Characterization of cxcr3.2−/− embryos in unchallenged conditions.

Volume 17, Issue 6, Pages (December 2009)

Gain and loss of Cdk5α induces overt neurodegeneration and degenerative phenotypes. Gain and loss of Cdk5α induces overt neurodegeneration and degenerative.

Kanyan Xu, Xiangzhong Zheng, Amita Sehgal Cell Metabolism

Volume 27, Issue 13, Pages e6 (July 2017)

Effect of cxcr3.2 mutation on dissemination of local mycobacterial infection within 24 hpi. Effect of cxcr3.2 mutation on dissemination of local mycobacterial.

Fig. 6. crb_C mutant photoreceptor cells exhibit normal morphology.

Volume 11, Issue 5, Pages (May 2010)

The human homolog of clu, CLUH, can rescue Drosophila clu mutant phenotypes. The human homolog of clu, CLUH, can rescue Drosophila clu mutant phenotypes.

Differential Cre-ERT activity and PTEN deletion in endometrial epithelial and stromal compartments. Differential Cre-ERT activity and PTEN deletion in.

Fig. 7. Motion adaptation increases time-dependent response modulations (TDRM) relatively to the average cell response.TDRM normalized to the value obtained.

A Drosophila cell culture model to study VAP(P58S) aggregation.

Fig. 4. Effect of royal jelly on silkmoth fat body cells and eggs.

Expression of RUNX2 correlates with ER/PR/HER2-negative human breast cancer. Expression of RUNX2 correlates with ER/PR/HER2-negative human breast cancer.

Embryonic corneal defects in E18.5 AP-2β NCC KO mutant embryos.

Inflammation is associated with increased basal-cell plasticity in the Nkx3.1 mutant prostate. Inflammation is associated with increased basal-cell plasticity.

Developmental defects in the svkA-null mutant.

TP53 western blot of primary cultured tail cells from both wild-type (WT) and Tp53Δ11/Δ11 (−/−) rats. TP53 western blot of primary cultured tail cells.

Fig. 4. Increased adipocyte differentiation in Cbx7-KO ES cells

Fig. 1. Body weight gain in Cbx7-KO mice

Fig. 2. DDR1 over-expression enhances collagen fibril reorganization

Forward and reverse genetic approaches in Drosophila.

Obesity affected the metabolic response to stroke.

Overexpression of Nedd4 is able to rescue miR-1-mediated actin fiber disarray in larval hearts. Overexpression of Nedd4 is able to rescue miR-1-mediated.

Hipk induces hemocyte-derived melanotic tumors.

Fig. 2. Two signal-producing behaviours of wild-type Canton-S males and per mutant males relative to whether the wild-type female is moving or immobile.

P53 is responsible for the induction of apoptosis, developmental malformations and mortality of G1 and G2tert mutant zebrafish. p53 is responsible for.

Response of BW YPO consomic males to glucose and insulin challenges.

Fig. 6. Effect of SAHA and ML on histone acetylation, BAX, and p21CDKN1A expression.PANC-1 and BxPC-3 cells were incubated for 48 hours with 5 µM.

Hipk induces overgrowths in Drosophila imaginal discs.

Kmt2b is required for SSC-to-progenitor transition.

Elevated expression of vegfaa in hemangiosarcoma.

Effects of overexpressing pk on polarity of cells in which either the Stan/Fz system (stan–) or the Ds/Ft system is broken (ft– d–), or both are broken.

Simultaneous perturbations to shuttling result in defects in the Dl gradient and in the sna domain. Simultaneous perturbations to shuttling result in defects.

Distribution and extent of expression.

Relationship between FFM, daily EI and daily profile of hunger.

Intestinal CAV1 deletion alters circulating FFAs but not TGs

Functional classification and visualization of differentially expressed genes. Functional classification and visualization of differentially expressed.

Statistical chart of significantly differentially expressed genes

Characterization of zebrafish muscle wasting in krasG12V-induced HCC zebrafish. 4-month-old male adult krasG12V and WT zebrafish were treated with dox.

Reb does not play a significant role in regulating TGF-β signaling

Fig. 1. Phenotypes of RasV12 transformed Drosophila lines

Homozygous col22a1−/− embryos show increased percentage of hemorrhages when raised at increased temperature. Homozygous col22a1−/− embryos show increased.

Impact of low-level galactose exposure on acute and long-term outcomes in GALT-null Drosophila. Impact of low-level galactose exposure on acute and long-term.

Compensatory hyperinsulinemia maintains euglycemia in HFHC-fed guinea pigs but is lost with STZ treatment. Compensatory hyperinsulinemia maintains euglycemia.

Systemic infection in Drosophila larvae by septic injury with a fine tungsten needle. Systemic infection in Drosophila larvae by septic injury with a fine.

Expression of transgenic IGF-1Ea propeptide in the skin reduces the severity of contact hypersensitivity responses. Expression of transgenic IGF-1Ea propeptide.

Food-additive exposure reduces adult fly survival under some feeding conditions. Food-additive exposure reduces adult fly survival under some feeding conditions.

Drs expression profiles for OreR flies infected with the various C

Ibm1 and edm2 mutants generate more stomatal divisions in the leaf epidermis. ibm1 and edm2 mutants generate more stomatal divisions in the leaf epidermis.

Stimulation of cells with FFAR4 agonist.

Fig. 6. IIS affected the soma area of most neurons in pharate adults, but not in larvae.(A,B) Pan-peptidergic expression pattern of 386-Gal4,UAS-CD8::GFP.

Loss of Graf results in plasmatocyte overproliferation.

HFHC/STZ guinea pigs develop insulin-independent diabetes that is responsive to oral antihyperglycemic therapy. HFHC/STZ guinea pigs develop insulin-independent.

Peroxisome speeds were slower in patient and control cells.

Matthew H. Sieber, Carl S. Thummel Cell Metabolism

mip120 null egg chambers have a condensed nurse cell DNA phenotype

Volume 17, Issue 5, Pages (October 2016)

Integrin-mediated signaling is required for PFC maturation.

WT MARCH8, but not the CS mutant, specifically ubiquitinates and downregulates TfR. WT MARCH8, but not the CS mutant, specifically ubiquitinates and downregulates.

Failure of chromosome disassembly in mip120 null ovarian nurse cells

Fig. 1. Effects of royal jelly on silkmoth body size.

Effects of paclitaxel and vinblastine.

Presentation transcript:

Obesity accompanied by increased triacylglyceride deposits in InsP3R mutants leads to starvation resistance. Obesity accompanied by increased triacylglyceride deposits in InsP3R mutants leads to starvation resistance. (A) Viability profile of wild-type (CS) adult female Drosophila and of the indicated genotypes upon starvation. Starvation profiles of control strains expressing itpr+ in IPCs and fat body cells of wild-type flies are shown in supplementary material Fig. S1C,D. IPC, insulin-producing cells; FB, fat body cells. (B) Nile Red (control, itprug3/+ and mutant, itprku) and Oil Red (itpr+ rescued itprku) stained lipid droplets in fat body cells of adult Drosophila. (C) Quantification of the number of Nile Red stained lipid droplets in mutant (itprku) and control (itprug3/+) fat body cells in fed (F) and starved (S) flies. The number of lipid droplets in 12 cells, selected randomly from three samples, is shown in the box plot. (D) The volume of 30 Nile Red stained lipid droplets obtained from three samples was calculated for each genotype (*P<0.05 as compared with fed control; Student’s t-test). (E) Average body weights of five adult females of the indicated genotypes at eclosion (0 hours), after 72 hours on a normal diet, or after 72 hours on a normal diet followed by 72 hours on either on a normal diet (F) or under starvation (S). Body weights of itprku were significantly higher than those of CS under similar conditions (*P<0.005; Student’s t-test). Manivannan Subramanian et al. Dis. Model. Mech. 2013;6:734-744 © 2013. Published by The Company of Biologists Ltd