Predictive performance of eleven pharmacokinetic models for propofol infusion in children for long-duration anaesthesia M Hara, K Masui, D.J. Eleveld,

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Presentation transcript:

Predictive performance of eleven pharmacokinetic models for propofol infusion in children for long-duration anaesthesia M Hara, K Masui, D.J. Eleveld, M.M.R.F. Struys, O Uchida British Journal of Anaesthesia Volume 118, Issue 3, Pages 415-423 (March 2017) DOI: 10.1093/bja/aex007 Copyright © 2017 The Author(s) Terms and Conditions

Fig 1 Measured plasma concentration (Cp) of propofol vs time. The dashed line connects measured Cps (filled circle) in each individual. British Journal of Anaesthesia 2017 118, 415-423DOI: (10.1093/bja/aex007) Copyright © 2017 The Author(s) Terms and Conditions

Fig 2 Predicted plasma concentration (Cp) of propofol by the 11 pharmacokinetic models vs time. The dashed line connects predicted CPs (filled circle) in each individual. British Journal of Anaesthesia 2017 118, 415-423DOI: (10.1093/bja/aex007) Copyright © 2017 The Author(s) Terms and Conditions

Fig 3 Prediction error (PE) by the 11 pharmacokinetic models vs time. The dashed line connects Pes (filled circle) in each individual. Red line depicts friedman's supersmoother curve indicating typical model behaviour in the population. The white band shows the PE range indicating good model performance, and the dark grey band shows the PE range indicating poor model performance. British Journal of Anaesthesia 2017 118, 415-423DOI: (10.1093/bja/aex007) Copyright © 2017 The Author(s) Terms and Conditions