Novel Equations for Estimating Lean Body Mass in Patients With Chronic Kidney Disease Xue Tian, MD, Yuan Chen, BN, Zhi-Kai Yang, MD, PhD, Zhen Qu, MD,

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Novel Equations for Estimating Lean Body Mass in Patients With Chronic Kidney Disease Xue Tian, MD, Yuan Chen, BN, Zhi-Kai Yang, MD, PhD, Zhen Qu, MD, PhD, Jie Dong, MD, PhD Journal of Renal Nutrition Volume 28, Issue 3, Pages 156-164 (May 2018) DOI: 10.1053/j.jrn.2017.09.004 Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Scatterplots, regression lines, and 95% confidence intervals (CIs) reflecting correlations between lean body mass measured using DEXA (LBM-DEXA) and mid-arm muscle circumference (MAMC) in the development group of 150 chronic kidney disease patients. Dotted lines reflect 95% CIs. Journal of Renal Nutrition 2018 28, 156-164DOI: (10.1053/j.jrn.2017.09.004) Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 Scatterplots, regression lines, and 95% confidence intervals (CIs) reflecting correlations between lean body mass measured using DEXA (LBM-DEXA) and handgrip strength (HGS) in the development group of 150 chronic kidney disease patients. Dotted lines reflect 95% CIs. Journal of Renal Nutrition 2018 28, 156-164DOI: (10.1053/j.jrn.2017.09.004) Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions

Figure 3 Bar plots of lean body mass (LBM) measured directly using dual-energy x-ray absorptiometry (LBM-DEXA), estimated by middle arm circumference (LBM-M) and handgrip strength (LBM-H) in the validation databases of 150 chronic kidney disease patients. Lower and upper bar boundaries are 25th and 75th percentiles, the line within the bar is the median. Journal of Renal Nutrition 2018 28, 156-164DOI: (10.1053/j.jrn.2017.09.004) Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions

Figure 4 Difference plot between lean body mass (LBM), measured directly using dual-energy x-ray absorptiometry (LBM-DEXA), and estimated using the equation based on mid-arm circumference (LBM-M) in the validation group of 150 chronic kidney disease patients. The medium dashed line is the difference and the others are the limits of agreement. Subgroups were defined by LBM above and below 44.65 kg. Journal of Renal Nutrition 2018 28, 156-164DOI: (10.1053/j.jrn.2017.09.004) Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions

Figure 5 Difference plot between lean body mass (LBM), measured directly using dual-energy x-ray absorptiometry (LBM-DEXA), and estimated using the equation based on handgrip strength (LBM-H) in the validation group of 150 chronic kidney disease patients. The medium dashed line is the difference and the others are the limits of agreement. Subgroups were defined by LBM above and below 44.65 kg. Journal of Renal Nutrition 2018 28, 156-164DOI: (10.1053/j.jrn.2017.09.004) Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions

Figure 6 Difference plot between lean body mass (LBM), measured directly using dual-energy x-ray absorptiometry (LBM-DEXA), and estimated using the equation based on mid-arm circumference (LBM-M) in the validation group of 150 chronic kidney disease (CKD) patients. The medium dashed line is the difference and the others are the limits of agreement. Subgroups were defined by CKD stage (estimated glomerular filtration rate 30-59 or <30 mL/minute/1.73 m2). Journal of Renal Nutrition 2018 28, 156-164DOI: (10.1053/j.jrn.2017.09.004) Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions

Figure 7 Difference plot between lean body mass (LBM), measured directly using dual-energy x-ray absorptiometry (LBM-DEXA), and estimated using the equation based on handgrip strength (LBM-H) in the validation group of 150 chronic kidney disease (CKD) patients. The medium dashed line is the difference and the others are the limits of agreement. Subgroups were defined by CKD stage (estimated glomerular filtration rate 30-59 or <30 mL/minute/1.73 m2). Journal of Renal Nutrition 2018 28, 156-164DOI: (10.1053/j.jrn.2017.09.004) Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions

Figure 8 Difference plot between lean body mass (LBM), measured directly using dual-energy x-ray absorptiometry (LBM-DEXA), and estimated using the equation based on mid-arm circumference (LBM-M) in the validation group of 150 chronic kidney disease patients. The medium dashed line is the difference and the others are the limits of agreement. Subgroups were defined by the ratio of extracellular water to total body water (<0.476 or ≥0.476). Journal of Renal Nutrition 2018 28, 156-164DOI: (10.1053/j.jrn.2017.09.004) Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions

Figure 9 Difference plot between lean body mass (LBM), measured directly using dual-energy x-ray absorptiometry (LBM-DEXA), and estimated using the equation based on handgrip strength (LBM-H) in the validation group of 150 chronic kidney disease patients. The medium dashed line is the difference and the others are the limits of agreement. Subgroups were defined by the ratio of extracellular water to total body water (<0.476 or ≥0.476). Journal of Renal Nutrition 2018 28, 156-164DOI: (10.1053/j.jrn.2017.09.004) Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions