Eric H. Raabe, Charles G. Eberhart Cancer Cell

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Methylome Alterations “Mark” New Therapeutic Opportunities in Glioblastoma Eric H. Raabe, Charles G. Eberhart Cancer Cell Volume 22, Issue 4, Pages 417-418 (October 2012) DOI: 10.1016/j.ccr.2012.10.001 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Similar Appearances, Different Methylomes, and Divergent Outcomes A pediatric midline GBM of the pons (a diffuse intrinsic pontine glioma, left) and a hemispheric glioblastoma multiforme arising in a young adult (right) have a similar histologic appearance on high power hematoxylin and eosin photomicrographs. Yet, as demonstrated by Sturm et al. (2012) in this issue of Cancer Cell, these two tumors affect different patient populations, arise in anatomically distinct regions, have different methylation profiles, and behave differently. For both images, magnification = 200× and scale bar = 100 μM. Cancer Cell 2012 22, 417-418DOI: (10.1016/j.ccr.2012.10.001) Copyright © 2012 Elsevier Inc. Terms and Conditions