JUDY L. SCHMIDT, M.D. Mayo Clinic Proceedings

Slides:

Advertisements

Similar presentations

Use of Doppler Techniques (Continuous-Wave, Pulsed-Wave, and Color Flow Imaging) in the Noninvasive Hemodynamic Assessment of Congenital Heart Disease.

Advertisements

My Treatment Approach to Hairy Cell Leukemia Rahul R. Naik, MD, Alan Saven, MD Mayo Clinic Proceedings Volume 87, Issue 1, Pages (January 2012) DOI:

Celebrating the Sesquicentennial of Mayo Clinic: 150 Years of Advances in Medical Practice, Education, Research, and Professionalism William L. Lanier,

Diverticulosis and Diverticulitis

Pleomorphic Adenoma in the Parotid Gland

Managing Cancer Pain: Basic Principles and Invasive Treatments

Rehabilitation in Multiple Sclerosis

Ductal Carcinoma in Situ of the Breast

Noninvasive Ventilation

Evaluation of Proteinuria

Diverticulosis and Diverticulitis

Ocular Motor Abnormalities in Wallenberg's Lateral Medullary Syndrome

Diagnostic Options for Assessment of Postmenopausal Bleeding

William L. Lanier, MD Mayo Clinic Proceedings

Diagnosis and Management of Chronic Kidney Disease

Treatment of Alcohol Withdrawal in Hospitalized Patients

Ayalew Tefferi, M.D. Mayo Clinic Proceedings

Obsessive Compulsive Disorder: A Clinical Update

68-Year-Old Woman With Dyspnea and Chest Pain

Michele A. Hanson, M.D., Daniel A. Dumesic, M.D.

The Shrinking Lungs Syndrome in Systemic Lupus Erythematosus

CHUNG H. KIM, M.D., MICHAEL G. SARR, M.D. Mayo Clinic Proceedings

Practical Considerations for Managing Asthma in Adults

JOANNE H. VAN WOERT, M.D. Mayo Clinic Proceedings

Gestational Trophoblastic Disease

Pulmonary Infiltrates and Eosinophilia Associated With Sulfasalazine

Palliative Care and Hospice Programs

Deep Venous Thrombosis of the Arm After Intravenous Immunoglobulin Infusion: Case Report and Literature Review of Intravenous Immunoglobulin-Related Thrombotic.

RICHARD K. WINKELMANN, M.D., Ph.D., J. CLARKE STEVENS, M.D.

45-Year-Old Man With Dermatitis and Weight Loss

Gerry H. Tan, M.D., Roger L. Nelson, M.D. Mayo Clinic Proceedings

The Melanoma Epidemic Thus Far

Carotid Sinus Syndrome and Wrestling

Madonna della Pietá by Michelangelo

CHARLES H. DICKEN, M.D. Mayo Clinic Proceedings

Photodynamic Therapy for Early Stage Central Type of Lung Cancer

Pancreatic Ductal Adenocarcinoma

MIGUEL A. VALDOVINOS, M. D. , MICHAEL CAMILLERI, M. D. , BRUCE R

The Mayo Legacy in Medical Education*

Treating Tobacco Dependence in Light of the 2008 US Department of Health and Human Services Clinical Practice Guideline J. Taylor Hays, MD, Jon O. Ebbert,

Refurbishing Mayo Clinic Proceedings:

Antidepressants and Brain Neurochemistry

Gastric Signet Ring Cell Carcinoma

Classic Hodgkin Lymphoma

Pleomorphic Adenoma in the Parotid Gland

22- Year-Old Man With Abdominal Pain and Rash

Renal Pyelocalyceal Squamous Cell Carcinoma

Jöns Jacob Berzelius – A Father of Chemistry

Cyclophosphamide-Induced Hepatitis in Wegener's Granulomatosis

Diabetic Mastopathy Mayo Clinic Proceedings

Allen D. Seftel, MD, Martin Kathrins, MD, Craig Niederberger, MD

Hepatocellular Carcinoma

Methylphenidate: Its Pharmacology and Uses

Postoperative Trouble

Pulmonary Tumor Embolism of Unknown Origin

Hepatitis C Genotypes: Current Trends and Future Implications

Celebrating the Sesquicentennial of Mayo Clinic: 150 Years of Advances in Medical Practice, Education, Research, and Professionalism William L. Lanier,

Medical Treatment of Overactive Bladder: In Response

Mark A. Marinella, MD, Kenneth Greene, MD Mayo Clinic Proceedings

Mantle Cell Involvement of the Spleen

Management of Immune Thrombocytopenic Purpura in Adults

Squamous Cell Carcinoma of the Tongue

Preoperative Smoking Cessation: The Role of the Primary Care Provider

Medical Student Distress: Causes, Consequences, and Proposed Solutions

Peripheral Tissue Examination for Malignant Lesions of the Skin

Managing Cancer Pain: Basic Principles and Invasive Treatments

Treatment of Antineutrophil Cytoplasm Autoantibody-Associated Systemic Vasculitis: Initiatives of the European Community Systemic Vasculitis Clinical.

A New Look at Osteoporosis Outcomes: The Influence of Treatment, Compliance, Persistence, and Adherence Enkhe Badamgarav, MD, MPH, Lorraine A. Fitzpatrick,

Mayo Clinic Proceedings 2012: “A New Era in Journal Stewardship”

Managing the Complications of Cirrhosis

Presentation transcript:

Thrombotic Thrombocytopenic Purpura: Successful Treatment Unlocks Etiologic Secrets* JUDY L. SCHMIDT, M.D. Mayo Clinic Proceedings Volume 64, Issue 8, Pages 956-961 (August 1989) DOI: 10.1016/S0025-6196(12)61223-3 Copyright © 1989 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 1 Diagram of one hypothesis for pathogenesis of platelet agglutination in thrombotic thrombocytopenic purpura. (1) A noxious stimulus produces (A) transient platelet-agglutinating factor (PAF) and may promote (B) release of unusually large multimers of factor VIII:von Willebrand factor (VIII:vWF). (2) Because of a relative insufficiency, immunoglobulin (λ) is unable to neutralize PAF or the unusually large multimers of VIII:vWF. (3) PAF then neutralizes negatively charged platelet surfaces and thus promotes platelet agglutination. (4) Platelet agglutination is augmented by the presence of unusually large multimers of VIII:vWF. Mayo Clinic Proceedings 1989 64, 956-961DOI: (10.1016/S0025-6196(12)61223-3) Copyright © 1989 Mayo Foundation for Medical Education and Research Terms and Conditions