Home use of closed-loop insulin delivery for overnight glucose control in adults with type 1 diabetes: a 4-week, multicentre, randomised crossover study

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Home use of closed-loop insulin delivery for overnight glucose control in adults with type 1 diabetes: a 4-week, multicentre, randomised crossover study Hood Thabit, MD, Alexandra Lubina-Solomon, PhD, Marietta Stadler, PhD, Lalantha Leelarathna, PhD, Emma Walkinshaw, MRCP, Andrew Pernet, RN, Janet M Allen, RN, Ahmed Iqbal, MRCP, Pratik Choudhary, MD, Kavita Kumareswaran, PhD, Marianna Nodale, MSc, Chloe Nisbet, BMedSci, Malgorzata E Wilinska, PhD, Katharine D Barnard, PhD, Prof David B Dunger, MD, Prof Simon R Heller, FRCP, Prof Stephanie A Amiel, FRCP, Mark L Evans, FRCP, Dr Roman Hovorka, PhD The Lancet Diabetes & Endocrinology Volume 2, Issue 9, Pages 701-709 (September 2014) DOI: 10.1016/S2213-8587(14)70114-7 Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 1 Trial design *Compliance assessed. The Lancet Diabetes & Endocrinology 2014 2, 701-709DOI: (10.1016/S2213-8587(14)70114-7) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 2 Trial profile The Lancet Diabetes & Endocrinology 2014 2, 701-709DOI: (10.1016/S2213-8587(14)70114-7) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 3 Median (IQR) of sensor glucose (A) and insulin delivery (B) during closed loop and control period for the 24 h duration Solid red line and red shaded area signify closed loop; dashed black line and peach shaded area signify control. The glucose range 3·9–8·0 mmol/L is denoted in panel A by horizontal black lines. The Lancet Diabetes & Endocrinology 2014 2, 701-709DOI: (10.1016/S2213-8587(14)70114-7) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 4 Individual values of time when glucose was in target glucose range of 3·9–8·0 mmol/L (A) and mean overnight glucose (B) The Lancet Diabetes & Endocrinology 2014 2, 701-709DOI: (10.1016/S2213-8587(14)70114-7) Copyright © 2014 Elsevier Ltd Terms and Conditions