Lymphocyte homing: The scent of a follicle

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Lymphocyte homing: The scent of a follicle Christopher C Goodnow, Jason G Cyster Current Biology Volume 7, Issue 4, Pages R219-R222 (April 1997) DOI: 10.1016/S0960-9822(06)00105-9

Figure 1 Simplified depiction of lymphoid tissue architecture and cell migration routes in spleen, lymph nodes and Peyer's patches. For the spleen, the diagram represents a single white pulp cord with the surrounding red pulp stripped away. Lymphocytes are released in the spleen from terminal arterioles that branch from central arterioles (ca) and frequently end in the marginal sinus that surrounds the lymphoid compartments. Lymphocytes enter lymph nodes and Peyer's patches across specialized high endothelial venules (hev), usually located in the T-cell zone. Red arrows indicate fluid and antigen movement (blood, lymph or intestinal fluid transcytosed by M cells); green arrows show T-cell migration; and blue arrows show B-cell migration. Blood leaves the spleen via venous sinuses in the red pulp that are not shown. Shaded B and T cell zones represent areas tightly packed with predominantly B or T cells, respectively. See text for further details of lymphocyte and antigen traffic. Current Biology 1997 7, R219-R222DOI: (10.1016/S0960-9822(06)00105-9)