Use of Targeted Temperature Management After Out-of-hospital Cardiac Arrest: A Meta- Analysis of Randomized Controlled Trials  Ahmed Mahmoud, MD, Islam.

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Use of Targeted Temperature Management After Out-of-hospital Cardiac Arrest: A Meta- Analysis of Randomized Controlled Trials  Ahmed Mahmoud, MD, Islam Y. Elgendy, MD, Anthony A. Bavry, MD, MPH  The American Journal of Medicine  Volume 129, Issue 5, Pages 522-527.e2 (May 2016) DOI: 10.1016/j.amjmed.2015.11.004 Copyright © 2016 Terms and Conditions

Figure 1 Summary plot for all-cause mortality according to longest follow-up duration. The relative size of the data markers indicates the weight of the sample size from each study. CI = confidence interval; HACA = Hypothermia After Cardiac Arrest Study Group; RR = risk ratio; TTM = targeted temperature management (32-34°C). The American Journal of Medicine 2016 129, 522-527.e2DOI: (10.1016/j.amjmed.2015.11.004) Copyright © 2016 Terms and Conditions

Figure 2 Summary plot for all-cause mortality after excluding the Nielsen et al trial.10 The relative size of the data markers indicates the weight of the sample size from each study. CI = confidence interval; RR = risk ratio. The American Journal of Medicine 2016 129, 522-527.e2DOI: (10.1016/j.amjmed.2015.11.004) Copyright © 2016 Terms and Conditions

Figure 3 Summary plot for poor neurological outcomes according to the longest follow-up duration. The relative size of the data markers indicates the weight of the sample size from each study. CI = confidence interval; RR = risk ratio. The American Journal of Medicine 2016 129, 522-527.e2DOI: (10.1016/j.amjmed.2015.11.004) Copyright © 2016 Terms and Conditions

Figure 4 Summary plot for poor neurological outcomes after excluding the Nielsen et al trial.10 The relative size of the data markers indicates the weight of the sample size from each study. CI = confidence interval; RR = risk ratio. The American Journal of Medicine 2016 129, 522-527.e2DOI: (10.1016/j.amjmed.2015.11.004) Copyright © 2016 Terms and Conditions

Supplementary Figure 1 Study selection diagram. The American Journal of Medicine 2016 129, 522-527.e2DOI: (10.1016/j.amjmed.2015.11.004) Copyright © 2016 Terms and Conditions

Supplementary Figure 2 Summary plot for all-cause mortality for shockable rhythms. CI = confidence interval; HACA = Hypothermia After Cardiac Arrest Study Group; TTM = targeted temperature management (32-34°C). The American Journal of Medicine 2016 129, 522-527.e2DOI: (10.1016/j.amjmed.2015.11.004) Copyright © 2016 Terms and Conditions

Supplementary Figure 3 Summary plot for poor neurological outcome for shockable rhythms. CI = confidence interval; HACA = Hypothermia After Cardiac Arrest Study Group; TTM = targeted temperature management (32-34°C). The American Journal of Medicine 2016 129, 522-527.e2DOI: (10.1016/j.amjmed.2015.11.004) Copyright © 2016 Terms and Conditions

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