Ovol Proteins: Guardians against EMT during Epithelial Differentiation

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Ovol Proteins: Guardians against EMT during Epithelial Differentiation Shan Li, Jing Yang Developmental Cell Volume 29, Issue 1, Pages 1-2 (April 2014) DOI: 10.1016/j.devcel.2014.04.002 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Ovol Proteins Guard Epithelial Differentiation by Suppressing EMT During normal development of the mammary gland and epidermis in mice (left), Ovol transcription factors suppress the expression of Zeb1 and the EMT program to safeguard epithelial identity during differentiation. Deletion of the Ovol proteins (right) causes excessive activation of the EMT program mainly through the upregulation of Zeb1 expression. Increased numbers of vimentin-positive cells (labeled in red) were evident in both the mammary TEB and epidermal basal cells. This misactivated EMT program interferes with proper epithelial differentiation and results in defects in mammary duct elongation and expansion of the epidermal basal compartment. Developmental Cell 2014 29, 1-2DOI: (10.1016/j.devcel.2014.04.002) Copyright © 2014 Elsevier Inc. Terms and Conditions