Primary respiratory and food allergy to mealworm

Slides:



Advertisements
Similar presentations
In vivo assessment with prick-to-prick testing and double-blind, placebo-controlled food challenge of allergenicity of apple cultivars Suzanne T.H.P. Bolhaar,
Advertisements

Detection of novel occupational wood allergens in locust wood dust (Robinia pseudoacacia L.)  Sabine Kespohl, PhD, Rolf Merget, MD, Axel Overlack, MD,
Allergic reactions to manioc (Manihot esculenta Crantz): Identification of novel allergens with potential involvement in latex-fruit syndrome  Keity Souza.
Allergenicity and safety of recombinant human C1 esterase inhibitor in patients with allergy to rabbit or cow's milk  Mignon T. van den Elzen, MD, Harmieke.
Shea butter contains no IgE-binding soluble proteins
Kuan-Wei Chen, PhD, Katharina Blatt, MSc, Wayne R
Kim A. B. M. Peeters, MD, André C. Knulst, MD, PhD, Frank J
Pharmacologic rationale for treating allergic and nonallergic rhinitis
High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE  Elizabeth A. Erwin,
Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD 
Lupine allergy: Not simply cross-reactivity with peanut or soy
Role of the basophil activation test in the diagnosis of local allergic rhinitis  Enrique Gómez, PhD, Paloma Campo, MD, PhD, Carmen Rondón, MD, PhD, Esther.
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Ann-Marie M. Schoos, MD, PhD, Jacob D
Giant ragweed specific immunotherapy is not effective in a proportion of patients sensitized to short ragweed: Analysis of the allergenic differences.
Allergic reactions to manioc (Manihot esculenta Crantz): Identification of novel allergens with potential involvement in latex-fruit syndrome  Keity Souza.
Act d 12 and Act d 13: Two novel, masked, relevant allergens in kiwifruit seeds  Sofía Sirvent, PhD, Belén Cantó, BSc, Javier Cuesta-Herranz, MD, PhD,
Julie Wang, MD, James H. Godbold, PhD, Hugh A. Sampson, MD 
Is 9 more than 2 also in allergic airway inflammation?
Bruce M. Prenner, MD, Bobby Q. Lanier, MD, David I
Heleen D. de Koning, MD, Joost Schalkwijk, PhD, Jos W. M
Firdaus Hamid, MD, PhD, Serge A. Versteeg, BSc, Aprilianto E
An Infant with Atopic Dermatitis and Itching After Ingestion of Milk
Allergenicity and safety of recombinant human C1 esterase inhibitor in patients with allergy to rabbit or cow's milk  Mignon T. van den Elzen, MD, Harmieke.
Shea butter contains no IgE-binding soluble proteins
In vivo allergenic activity of a hypoallergenic mutant of the major fish allergen Cyp c 1 evaluated by means of skin testing  Nikolaos Douladiris, MD,
BCG vaccination and allergy: A systematic review and meta-analysis
Analysis of serum IgE reactivity profiles with microarrayed allergens indicates absence of de novo IgE sensitizations in adults  Christian Lupinek, MD,
Allergy testing in predicting outcome of open food challenge to peanut
Clinical studies of the DP1 antagonist laropiprant in asthma and allergic rhinitis  George Philip, MD, Janet van Adelsberg, MD, Thomas Loeys, PhD, Nancy.
Expression of FcɛRI on dendritic cell subsets in peripheral blood of patients with atopic dermatitis and allergic asthma  Inge M.J. Beeren, MSc, Marjolein.
Peter M. Wolfgram, MD, David B. Allen, MD 
Allergen microarray detects high prevalence of asymptomatic IgE sensitizations to tropical pollen-derived carbohydrates  Clarissa R. Cabauatan, PhD, Christian.
Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy  Annebeth E. Flinterman, MD, Edward F. Knol,
Approaches to the diagnosis and management of patients with a history of nonsteroidal anti-inflammatory drug–related urticaria and angioedema  Marek L.
Serum tryptase levels in atopic and nonatopic children
Respiratory sensitization of a worker to the warehouse beetle Trogoderma variabile: An index case report  Jonathan A. Bernstein, MD, Marjorie S. Morgan,
Component-resolved diagnosis of kiwifruit allergy with purified natural and recombinant kiwifruit allergens  Merima Bublin, PhD, Marina Pfister, MD, Christian.
A novel allergen-specific therapy with CD40-silenced B cells and dendritic cells  Motohiko Suzuki, MD, PhD, Makoto Yokota, MD, PhD, Yoshihisa Nakamura,
Food allergy in patients with primary immunodeficiency diseases: Prevalence within the US Immunodeficiency Network (USIDNET)  Karen S. Tuano, MD, Jordan.
Anna Nowak-Wegrzyn, MD, Katherine A. Bloom, MD, Scott. H
Allergen reference doses for precautionary labeling (VITAL 2
Biosimilars and drug development in allergic and immunologic diseases
Effect of day care attendance on sensitization and atopic wheezing differs by Toll-like receptor 2 genotype in 2 population-based birth cohort studies 
Effect of ingested H1 antihistamines on methacholine challenge
Kuan-Wei Chen, PhD, Katharina Blatt, MSc, Wayne R
Autophagy: Nobel Prize 2016 and allergy and asthma research
Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment
Advances in the approach to the patient with food allergy
Spiking venom with rVes v 5 improves sensitivity of IgE detection in patients with allergy to Vespula venom  Byrthe Vos, Julian Köhler, Sabine Müller,
Risk of oral food challenges
Sensitization to Cor a 9 and Cor a 14 is highly specific for a hazelnut allergy with objective symptoms in Dutch children and adults  Laury J.N. Masthoff,
Nasal inflammatory mediators and specific IgE production after nasal challenge with grass pollen in local allergic rhinitis  Carmen Rondón, MD, PhD, Javier.
Does “autoreactivity” play a role in atopic dermatitis?
Identification and characterization of a novel allergen from Blomia tropicalis: Blo t 21  Yun Feng Gao, BEng, De Yun Wang, MD, PhD, Tan Ching Ong, PhD,
Heather Lemon-Mulé, MD, Hugh A. Sampson, MD, Scott H
Efficacy and safety of sublingual tablets of house dust mite allergen extracts: Results of a dose-ranging study in an environmental exposure chamber 
Peanut oral immunotherapy decreases IgE to Ara h 2 and Ara h 6 but does not enhance sensitization to cross-reactive allergens  Riikka Uotila, MD, Anna.
Jessica H. Savage, MD, MHS, Elizabeth C. Matsui, MD, MHS, Robert A
Lipid transfer protein–linked hazelnut allergy in children from a non-Mediterranean birch- endemic area  Annebeth E. Flinterman, MD, Jaap H. Akkerdaas,
Epicutaneous application of house dust mite induces thymic stromal lymphopoietin in nonlesional skin of patients with atopic dermatitis  Janneke Landheer,
Macrolide antibiotics and asthma treatment
Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy– treated mother  Sabine Flicker, PhD, Katharina Marth, MD, Heinz.
Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization.
Dendritic cells in nasal mucosa of subjects with different allergic sensitizations  Susanne M. Reinartz, MD, Joost van Tongeren, MD, Danielle van Egmond,
IgE sensitization profiles toward green and gold kiwifruits differ among patients allergic to kiwifruit from 3 European countries  Merima Bublin, MSc,
The effects of an H3 receptor antagonist (PF ) with fexofenadine on reducing allergic rhinitis symptoms  Jeffrey R. Stokes, MD, Francisco A. Romero,
Role of Art v 3 in pollinosis of patients allergic to Pru p 3
Natural history of cow’s milk allergy
The Editors' Choice Journal of Allergy and Clinical Immunology
Presentation transcript:

Primary respiratory and food allergy to mealworm Henrike C.H.P. Broekman, MD, André C. Knulst, MD, PhD, Constance F. den Hartog Jager, BSc, Jolanda H.M. van Bilsen, PhD, Florine M.L. Raymakers, RN, Astrid G. Kruizinga, PhD, Marco Gaspari, PhD, Caterine Gabriele, PhD, Carla A.F.M. Bruijnzeel-Koomen, MD, PhD, Geert F. Houben, PhD, Kitty C.M. Verhoeckx, PhD  Journal of Allergy and Clinical Immunology  Volume 140, Issue 2, Pages 600-603.e7 (August 2017) DOI: 10.1016/j.jaci.2017.01.035 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 IgE-binding profile in mice and human subjects. A, Antibody responses (IgE and IgG1) to mealworm extract, shrimp extract, and control (PBS) in a mouse model on day 16. Data represent the mean log2 antibody titer ± SEM. Horizontal dotted lines represent detection limits of the assays (minimum/maximum). B, Subjects show IgE binding to allergens in both the mealworm and shrimp extracts. No binding is seen to Pen a 1 (shrimp tropomyosin) IgE from patients with mealworm food allergy; subjects 3 and 4 additionally bind to proteins with low molecular weight. Journal of Allergy and Clinical Immunology 2017 140, 600-603.e7DOI: (10.1016/j.jaci.2017.01.035) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Patients' characteristics. A, Mealworm exposure and clinical history to direct inhalation (while working with the animal) and ingestion of mealworm, HDM, and shrimp. AA, allergic asthma; AD, atopic dermatitis; AR, Allergic rhinitis; C, conjunctivitis; D, dyspnea; Dom, domestic farmer; F, female; GI, gastrointestinal; M, male; N, nasal congestion; OA, oral allergy; OFC, oral food challenge; Prof, professional farmer; R, rhinitis; S, sneezing; U, general urticaria; W, wheezing. B, Sensitization in SPTs, CAP tests, and ISAC tests (with at least 1 subject <0.3 ISU) for mealworm, HDM, and shrimp are included in the table. Der p 1, HDM peptidase C1; Der p 2, HDM NPC2 family; Der p 10, HDM tropomyosin; Pen m 1, shrimp tropomyosin. C, Challenge results. neg, Negative; pos, positive. Journal of Allergy and Clinical Immunology 2017 140, 600-603.e7DOI: (10.1016/j.jaci.2017.01.035) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Functional IgE binding. BATs showing basophil activation to mealworm proteins (Tris/urea extract) and shrimp (SPT, ALK-Abelló). No reactivity to Pen a 1 (shrimp tropomyosin) was seen. Clinically, subjects 1 and 2 showed respiratory symptoms to mealworm; subjects 3 and 4 showed food-induced allergic symptoms. Journal of Allergy and Clinical Immunology 2017 140, 600-603.e7DOI: (10.1016/j.jaci.2017.01.035) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Three patients with mealworm allergy sensitized to the LCP A1A on immunoblotting. Both patients 3 and 4 with food allergy show IgE binding to the mealworm LCP A1A. IgE from 1 subject with inhalant allergy bound to LCP A1A. Journal of Allergy and Clinical Immunology 2017 140, 600-603.e7DOI: (10.1016/j.jaci.2017.01.035) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions