Tipping the Balancing ACT

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Presentation transcript:

Tipping the Balancing ACT Shari Pilon-Thomas, Brian Ruffell Cancer Cell Volume 30, Issue 3, Pages 367-368 (September 2016) DOI: 10.1016/j.ccell.2016.08.012 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Tip-DCs Are Necessary for Adoptive T Cell Therapy CD40L on exogenously administered anti-tumor CD8+ T cells combines with CD40L expression by endogenous CD8+ T cells to drive expression of NOS2 by monocyte-derived Tip-DCs within tumors. Production of NO− by Tip-DCs may indirectly support a T cell response or may be directly cytotoxic toward tumor cells, leading to improved survival of tumor-bearing mice treated with ACT. Cancer Cell 2016 30, 367-368DOI: (10.1016/j.ccell.2016.08.012) Copyright © 2016 Elsevier Inc. Terms and Conditions