Topical Agents for the Management of Musculoskeletal Pain Steven P. Stanos, DO  Journal of Pain and Symptom Management  Volume 33, Issue 3, Pages 342-355 (March 2007) DOI: 10.1016/j.jpainsymman.2006.11.005 Copyright © 2007 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 1 Anatomy and physiology of the skin with the potential targets or sites of action of selected analgesics. Adapted from Ref. 14. Journal of Pain and Symptom Management 2007 33, 342-355DOI: (10.1016/j.jpainsymman.2006.11.005) Copyright © 2007 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 2 TRP family receptors and their thermosensitivity (adapted from Ref. 69). Journal of Pain and Symptom Management 2007 33, 342-355DOI: (10.1016/j.jpainsymman.2006.11.005) Copyright © 2007 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 3 Acute activation of the TRPV1 receptor leads to local intracellular calcium signals and the sensation of heat or burning pain. TRPV-transient receptor potential vanilloid. Reprinted with permission from Ref. 6. Journal of Pain and Symptom Management 2007 33, 342-355DOI: (10.1016/j.jpainsymman.2006.11.005) Copyright © 2007 U.S. Cancer Pain Relief Committee Terms and Conditions