Cell Migration: Making the Waves Jan Müller, Michael Sixt  Current Biology  Volume 27, Issue 1, Pages R24-R25 (January 2017) DOI: 10.1016/j.cub.2016.11.035 Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 1 A model describing the interplay between adhesion, protrusion and membrane tension. Keratocytes plated on substrates of intermediate adhesiveness show continuous protrusion of the leading edge. On highly adhesive substrates, the cells switch to an oscillatory ‘waving’ behavior. Three feedback loops govern wave formation in keratocytes migrating on high concentrations of RGD peptide, i.e. under high adhesion conditions: (1) large adhesions forming on high RGD accumulate large amounts of VASP, which is therefore depleted from the leading edge; (2) global inhibition of protrusion by increased membrane tension (denoted by large grey arrows); and (3) local positive feedback of increased protrusion on branching at the site of wave formation drives the propagation of the wave across the leading edge. Current Biology 2017 27, R24-R25DOI: (10.1016/j.cub.2016.11.035) Copyright © 2017 Elsevier Ltd Terms and Conditions