Keratin intermediate filament retraction is linked to plakoglobin-dependent signaling in pemphigus vulgaris Eliane J. Müller, PhD, Thomas Hunziker, MD,

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Keratin intermediate filament retraction is linked to plakoglobin-dependent signaling in pemphigus vulgaris Eliane J. Müller, PhD, Thomas Hunziker, MD, Maja M. Suter, PhD, Dr VetMed Journal of the American Academy of Dermatology Volume 56, Issue 5, Pages 890-891 (May 2007) DOI: 10.1016/j.jaad.2006.10.989 Copyright © 2007 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Keratin retraction in mouse keratinocyte cultures after 24 hours of treatment with normal human IgG (nhIgG) or pemphigus patients IgG (PVIgG). Immunofluorescence analysis shows retracted keratin intermediate filaments (red) from plasma membranes. At that time point, the plasma membranes of neighboring cells were still adjacent, as exemplified by the merge with the staining for adherens junction components (E-cadherin; green), while intercellular adhesive strength was already reduced.2,4 The “ruffled membranes” likely indicate alterations in signaling cascades relating to small GTPases. Journal of the American Academy of Dermatology 2007 56, 890-891DOI: (10.1016/j.jaad.2006.10.989) Copyright © 2007 American Academy of Dermatology, Inc. Terms and Conditions