South African amaXhosa patients with atopic dermatitis have decreased levels of filaggrin breakdown products but no loss-of-function mutations in filaggrin

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South African amaXhosa patients with atopic dermatitis have decreased levels of filaggrin breakdown products but no loss-of-function mutations in filaggrin Fatemah Thawer-Esmail, MD, FCDermSA, Ivone Jakasa, PhD, Gail Todd, FFDerm (SA), PhD, Yaran Wen, PhD, Sara J. Brown, MD, Karin Kroboth, MSc, Linda E. Campbell, BSc, Grainne M. O'Regan, MRCPI, W.H. Irwin McLean, DSc, FMedSci, Alan D. Irvine, MD, Sanja Kezic, PhD, Aileen Sandilands, PhD Journal of Allergy and Clinical Immunology Volume 133, Issue 1, Pages 280-282.e2 (January 2014) DOI: 10.1016/j.jaci.2013.09.053 Copyright © 2013 The Authors Terms and Conditions

Fig 1 Levels of filaggrin degradation products in the SC of healthy controls (Ctrl, n = 81) and patients with AD (n = 69) (median with interquartiles). FAA + derivatives, FAA including UCA, PCA, citrulline, and ornithine. ***P < .001 as determined by the 2-tailed Wilcoxon-Mann-Whitney test. Journal of Allergy and Clinical Immunology 2014 133, 280-282.e2DOI: (10.1016/j.jaci.2013.09.053) Copyright © 2013 The Authors Terms and Conditions

Fig E1 Amino acid composition of filaggrin. Ala, Alanine; Arg, arginine; Asn, asparagine; Asp, aspartate; Cys, cysteine; Gln, glutamine; Glu, glutamate; Gly, glycine; His, histidine; Ile, isoleucine; Leu, leucine; Lys, lysine; Met, methionine; Phe, phenylalanine; Pro, proline; Ser, serine; Thr, threonine; Trp, tryptophan; Tyr, tyrosine; Val, valine. Journal of Allergy and Clinical Immunology 2014 133, 280-282.e2DOI: (10.1016/j.jaci.2013.09.053) Copyright © 2013 The Authors Terms and Conditions