Figure 1 Pathogenesis of diabetic neuropathy

Slides:

Advertisements

Similar presentations

Isfahan University Of Medical Sciences

Advertisements

NERVE PATHOLOGY David Lacomis, MD. Nerve Biopsy  Major indication is “vasculitis”  May not show specific cause of neuropathy in most cases.

Diabetic Retinopathy (DR) Ayesha S Abdullah

Date of download: 7/9/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Small-Diameter Nerve Fiber Neuropathy in Systemic.

Research, Medical Students, and Physicians: Personal Experience

Nat. Rev. Neurol. doi:10/1038/nrneurol

From: Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain Invest. Ophthalmol.

Hereditary sensory and autonomic neuropathy type 1

Figure 3 Life expectancy at birth in all countries included

Nat. Rev. Neurol. doi: /nrneurol

NERVE PATHOLOGY David Lacomis, MD.

Nat. Rev. Neurol. doi: /nrneurol

Figure 2 The US Centers for Disease Control and

Figure 1 Carotid artery inflammation detected using 18F-FDG-PET

Nat. Rev. Neurol. doi: /nrneurol

Figure 1. Absence of anti–neurofascin-155 (NF155) antibodies in combined central and peripheral demyelination (CCPD)‏ Absence of anti–neurofascin-155 (NF155)

Nat. Rev. Neurol. doi: /nrneurol

Figure 2 Proposed mechanism of Guillain–Barré

Nat. Rev. Neurol. doi: /nrneurol

Figure 1 General framework of brain–computer interface (BCI) systems

Figure S1 Diabetes mellitus N =8 - No neuropathy

Nat. Rev. Neurol. doi: /nrneurol

Protein Networks in Alzheimer’s Disease

Figure 3 Proportion of patients for whom NEDA

Figure 5 Number of AHSCT procedures for

Nat. Rev. Neurol. doi: /nrneurol

Nat. Rev. Nephrol. doi: /nrneph

P. James B. Dyck, MD, Jennifer A. Tracy, MD Mayo Clinic Proceedings

Figure Sural nerve electron microscopy

Nat. Rev. Neurol. doi: /nrneurol

Nat. Rev. Neurol. doi: /nrneurol

Figure 1 Clinical correlates of neurodegeneration in MS

Nat. Rev. Neurol. doi: /nrneurol

Figure 1 Evolution of multiple sclerosis

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Neurol. doi: /nrneurol

Nat. Rev. Neurol. doi: /nrneurol

Figure 1 Anatomical patterns of neuropathy

Nat. Rev. Neurol. doi: /nrneurol

Figure 3 Stroke-related deaths and DALYs by country development status

Figure 4 11C-PK11195-PET scans showing the evolution of neuroinflammation in a patient after stroke Figure 4 | 11C-PK11195-PET scans showing the evolution.

Figure 6 Vascular dysfunction in epilepsy

Figure 3 VEGF in neurodegenerative disease

Figure 3 Current model of immunopathogenesis in CIDP

Figure 6 Combining population-wide and high-risk strategies

Nat. Rev. Nephrol. doi: /nrneph

Figure 2 Logistical requirements for autologous

Figure 3 Potential interplay between physiological

Nat. Rev. Neurol. doi: /nrneurol

Figure 1 Clinical aspects of LGMD subtypes

Figure 2 Cellular pathways implicated in CIPN

Figure 4 Diagnosing neuropathic pain

(A) Confocal image of a skin biopsy taken from the finger of a healthy subject illustrating different subtypes of sensory fibre: PGP 9.5 is used as an.

Adapted with permission from Tesfaye, S. , Boulton, A. J

(A) Confocal image of a skin biopsy taken from the finger of a healthy subject illustrating different subtypes of sensory fibre: PGP 9.5 is used as an.

Figure 4 Representative images of skin biopsy sample

Representative photomicrograph of small airways abnormalities in a subject with chronic obstructive pulmonary disease. Representative photomicrograph of.

Figure 1 Timing of the effects of deep brain stimulation

Figure 1 A large number of genes are potentially associated with CIPN

Confocal images of skin biopsies taken from the legs of a control subject (A) and a patient with small fibre neuropathy secondary to HIV (B) showing PGP.

Nat. Rev. Neurol. doi: /nrneurol

Confocal images of skin biopsies taken from the legs of a control subject (A) and a patient with small fibre neuropathy secondary to HIV (B) showing PGP.

Microphotographs (×20) of endobronchial biopsies from a) healthy control, b) mildly asthmatic and c) severe asthmatic airways demonstrating increased thickness.

Figure 3 Blood–brain barrier breakdown promotes neurodegeneration

Figure 2 Histopathological features in CIDP

Figure 2 Brain biopsy of 2 patients with anti-MOG encephalitis initially misdiagnosed with small vessel CNS vasculitis Brain biopsy of 2 patients with.

Higher levels of PEDF-impaired skin structure and function.

Figure 3 Bilateral optic atrophy and sural nerve biopsy of patient AII-2 Bilateral optic atrophy and sural nerve biopsy of patient AII-2 (A) Red-free photographs.

Proposed model of infection of peripheral nerve by M

Light and electron micrographs in the cauda equina at the site of constriction after 3 weeks.A, Light microscopy revealed nerve fiber degeneration. Light.

Presentation transcript:

Figure 1 Pathogenesis of diabetic neuropathy Figure 1 | Pathogenesis of diabetic neuropathy. Diabetic neuropathy has a complex pathogenesis involving interaction of axonopathy, schwannopathy and microvasculopathy. The figure shows the anatomical organization of myelinated and unmyelinated axons within nerve fascicles. Their nutrient supply is secured via endoneurial capillaries which, together with the perineurial membrane, form the blood–nerve barrier. a | Human skin biopsy samples immunostained with PGP9.5 to show progression of peripheral nerves from the dermis into the epidermis, where they exist as small unmyelinated C-fibres (scale bar 40 µm). Left panel shows loss of fibres in a patient with diabetic neuropathy and right panel shows fibres in a healthy individual. b | Changes in axons and myelin in diabetic neuropathy, showing degeneration of Schwann cells and nerve fibres, culminating in nerve and intraepidermal fibre loss. c | Endoneurial capillaries from patients with diabetes. Top panel shows a capillary from a patient without diabetic neuropathy, and bottom panel shows a capillary from a patient with neuropathy, in which endothelial cell hyperplasia and basement membrane thickening have reduced the size of the capillary lumen. d | Narrowing of individual capillaries might not prevent blood from passing through the endoneurial capillary bed per se, but the resulting increase in velocity of blood through endoneurial functional shunts or epineurial arteriovenous shunts prevents efficient oxygen extraction, causing hypoxia. Panel a courtesy of Dr Páll Karlsson, Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Denmark. Panel a courtesy of Dr Páll Karlsson, Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Denmark. Gonçalves, N. P. et al. (2017) Schwann cell interactions with axons and microvessels in diabetic neuropathy Nat. Rev. Neurol. doi:10.1038/nrneurol.2016.201