Arjun Pennathur, MD, Liqiang Xi, MD, Virginia R. Litle, MD, William E

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Gene expression profiles in esophageal adenocarcinoma predict survival after resection Arjun Pennathur, MD, Liqiang Xi, MD, Virginia R. Litle, MD, William E. Gooding, MS, Alyssa Krasinskas, MD, Rodney J. Landreneau, MD, Tony E. Godfrey, PhD, James D. Luketich, MD The Journal of Thoracic and Cardiovascular Surgery Volume 145, Issue 2, Pages 505-513 (February 2013) DOI: 10.1016/j.jtcvs.2012.10.031 Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Kaplan-Meier plot of estimated overall survival for study cohort. Dotted lines denote 95% confidence band for probability of survival. Median survival was 27 months (lower 95% confidence interval, 22 months). The Journal of Thoracic and Cardiovascular Surgery 2013 145, 505-513DOI: (10.1016/j.jtcvs.2012.10.031) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Hierarchical clustering of 59 genes selected for classification. Hierarchical clustering of gene expression data with patients in columns and genes in rows. The 59 genes selected for classification are labeled with their gene symbols. The heat map shows actual gene expression on the log 2 scale. Clustering determined by Euclidean distance of logged expression data. Column dendrogram shows patient risk groups: group A (low risk; n = 25 patients) and group B (high-risk; n = 39 patients). The Journal of Thoracic and Cardiovascular Surgery 2013 145, 505-513DOI: (10.1016/j.jtcvs.2012.10.031) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Kaplan-Meier plot of estimated overall survival stratified by gene expression profile, identified by unsupervised hierarchical clustering in Figure 2. Group A had markedly better survival than group B, corresponding to low- and high-risk gene expression profiles, respectively. The log-rank test was significant (P < .0001). The Journal of Thoracic and Cardiovascular Surgery 2013 145, 505-513DOI: (10.1016/j.jtcvs.2012.10.031) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Classification of patients with supervised principle components analysis. Three principal components were used to estimate a risk score for each patient according to their expression of the 59 genes. The risk score was divided into 2 groups at the median. A, Comparison of low- and high-risk patient cohorts (P < .0001). B, Same classification, using average of 100, 10-fold cross-validations to derive the risk score (P = .0005). The Journal of Thoracic and Cardiovascular Surgery 2013 145, 505-513DOI: (10.1016/j.jtcvs.2012.10.031) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 5 Multivariate analysis. Red vertical line depicts hazard ratio of 1, indicating no effect. All factors remained significant at P < .05. Hazard ratio for gene signature, adjusting for T stage and N stage, was 2.2. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 505-513DOI: (10.1016/j.jtcvs.2012.10.031) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions