Jeffrey A. Jones, PhD, Juozas A. Zavadzkas, MD, Eileen I

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Presentation transcript:

Cellular phenotype transformation occurs during thoracic aortic aneurysm development Jeffrey A. Jones, PhD, Juozas A. Zavadzkas, MD, Eileen I. Chang, BS, Nina Sheats, BS, Christine Koval, BS, Robert E. Stroud, MS, Francis G. Spinale, MD, PhD, John S. Ikonomidis, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 140, Issue 3, Pages 653-659 (September 2010) DOI: 10.1016/j.jtcvs.2009.12.033 Copyright © 2010 Terms and Conditions

Figure 1 Analysis of gene expression after cellular stimulation. Relative gene expression in normal and TAA fibroblast cell lines was analyzed in the absence (steady-state) or presence of biological stimuli. Cells were treated with 1nM ET-1, 100nM AngII, or 100nM PMA for 24hours and then analyzed by QPCR. Relative fold expression results were clustered in functional groups (MMP/TIMP, collagen/elastin, other ECM), and total gene expression was depicted as an area profile on a radar plot. Each axis displays the sum of the relative fold change in gene expression for a given gene cluster in the TAA fibroblasts compared with the control fibroblasts. MMP/TIMP, Matrix metalloproteinase/tissue inhibitor of metalloproteinase; TAA, thoracic aortic aneurysm; ECM, extracellular matrix; ET, endothelin; PMA, phorbol-12-myristate-13-acetate; AngII, angiotensin-II. The Journal of Thoracic and Cardiovascular Surgery 2010 140, 653-659DOI: (10.1016/j.jtcvs.2009.12.033) Copyright © 2010 Terms and Conditions