MicroRNA profiling in duodenal ulcer disease caused by Helicobacter pylori infection in a Western population S. Lario, M.J. Ramírez-Lázaro, A.M. Aransay,

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Presentation transcript:

microRNA profiling in duodenal ulcer disease caused by Helicobacter pylori infection in a Western population S. Lario, M.J. Ramírez-Lázaro, A.M. Aransay, J.J. Lozano, A. Montserrat, Á. Casalots, F. Junquera, J. Álvarez, F. Segura, R. Campo, X. Calvet Clinical Microbiology and Infection Volume 18, Issue 8, Pages E273-E282 (August 2012) DOI: 10.1111/j.1469-0691.2012.03849.x Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Study flow diagram. Clinical Microbiology and Infection 2012 18, E273-E282DOI: (10.1111/j.1469-0691.2012.03849.x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Expression profile of the selected miRNAs in H. pylori-infected patients according to endoscopic findings. (a) miR-9, miR-96, miR-146a, miR-155, miR-204 and miR-650 expression was not different between normal and duodenal ulcer patients. (b) Expression of the ‘housekeeping’ microRNA miR-98. Mann–Whitney U-test. Box plots show the 25th, 50th (median), 75th and range (whiskers). Clinical Microbiology and Infection 2012 18, E273-E282DOI: (10.1111/j.1469-0691.2012.03849.x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 3 Expression profile of the selected miRNAs in dyspeptic patients according to gastritis activity. (a) miR-9, miR-146a, miR-155 and miR-650 are up-regulated in patients with chronic active gastritis but not in patients with non-active gastritis. (b) miR-96 and miR-204 are down-regulated in patients with chronic active gastritis but not in patients with non-active gastritis. (c) Gastritis activity has no effect on the ‘housekeeping’ miR-98. Kruskal-Wallis H-test. Box plots show the 25th, 50th (median), 75th and range (whiskers). Clinical Microbiology and Infection 2012 18, E273-E282DOI: (10.1111/j.1469-0691.2012.03849.x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 4 Correlation plots for the selected miRNAs in relation to gastritis activity. rs, Spearman's correlation coefficient. Clinical Microbiology and Infection 2012 18, E273-E282DOI: (10.1111/j.1469-0691.2012.03849.x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 5 mRNA gene expression of selected interleukins (a), signalling molecules (b) and the housekeeping gene (c) in relation to gastritis activity. Kruskal-Wallis H-test. Box plots show the 25th, 50th (median), 75th and range (whiskers). Clinical Microbiology and Infection 2012 18, E273-E282DOI: (10.1111/j.1469-0691.2012.03849.x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions