ILCs and T Cells Competing for Space: More Than a Numbers Game Christin Friedrich, Georg Gasteiger  Immunity  Volume 47, Issue 1, Pages 8-10 (July 2017) DOI: 10.1016/j.immuni.2017.07.003 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 ILCs Regulate T Cell Homeostasis by Restricting IL-7 Availability in Secondary Lymphoid Organs In secondary lymphoid organs, radioresistant (stromal) cells constitutively produce the T cell mitogenic cytokine IL-7, which, together with TCR signals, is required for homeostatic proliferation. In naive T cells, binding of IL-7 to IL-7R activates downstream PI3K-AKT-dependent pathways, resulting in FOXO1 phosphorylation and subsequent nuclear export and degradation of FOXO1, which regulates IL-7Rα expression. Importantly, ILCs do not degrade FOXO1 in an AKT-dependent manner and maintain expression of IL-7Rα in the presence of IL-7, allowing them to consume increased amounts of IL-7. Immunity 2017 47, 8-10DOI: (10.1016/j.immuni.2017.07.003) Copyright © 2017 Elsevier Inc. Terms and Conditions