Facilitating the Design of Fluorinated Drugs Klaus Müller, Hans-Joachim Böhm  Chemistry & Biology  Volume 16, Issue 11, Pages 1130-1131 (November 2009) DOI: 10.1016/j.chembiol.2009.11.004 Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 1 Chemical Structure of the Ligand tBuBrettPhos This ligand was used in the studies by Watson et al. (2009). Chemistry & Biology 2009 16, 1130-1131DOI: (10.1016/j.chembiol.2009.11.004) Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 2 Typical Reaction Scheme for the Synthetic Method Developed by Watson et al. (2009). Key advancements are the use of CsF as a source of fluorine and the biaryl monophospine tBuBrettPhos as a hydrophobic Pd-ligand for the regiospecific aryl fluorination by reductive elimination from ary-tBuBrettPhos-Pd(II)-F intermediates. Chemistry & Biology 2009 16, 1130-1131DOI: (10.1016/j.chembiol.2009.11.004) Copyright © 2009 Elsevier Ltd Terms and Conditions