Lasker Laurels for Telomerase

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Lasker Laurels for Telomerase Titia de Lange Cell Volume 126, Issue 6, Pages 1017-1020 (September 2006) DOI: 10.1016/j.cell.2006.09.004 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 The Discovery of Telomerase and Its Role in Cellular Proliferation (A) The telomerase assay performed by Greider and Blackburn, using extracts of the ciliate Tetrahymena at various time points after mating, showed telomerase activity at the time of extensive de novo telomere synthesis (Greider and Blackburn, 1985). (B) Plasmid resolution assay used by Lundblad and Szostak to screen for yeast mutants deficient in telomere synthesis (Lundblad and Szostak, 1989). (C) Plate showing the delayed senescence phenotype of the est1-1 (“ever shortening telomeres”) yeast mutant that has a defect in telomerase (Lundblad and Szostak, 1989). Cell 2006 126, 1017-1020DOI: (10.1016/j.cell.2006.09.004) Copyright © 2006 Elsevier Inc. Terms and Conditions