A win in protection against ischemia-reperfusion injury?

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Presentation transcript:

A win in protection against ischemia-reperfusion injury? Tyson A. Fricke, MBBS, BMedSci, Igor E. Konstantinov, MD, PhD, FRACS The Journal of Thoracic and Cardiovascular Surgery DOI: 10.1016/j.jtcvs.2018.07.083 Copyright © 2018 Terms and Conditions

Figure 1 Pathways of cannabinoid receptor-mediated protection against ischemia-reperfusion (IR) injury. Cannabinoid receptor ligand (WIN55212-2) binding to cannabinoid receptors may reduce apoptosis and decrease proinflammatory cytokines and nitric oxide (NO) by increasing cytosolic inhibitory kBα, thus decreasing nuclear translocation of nuclear factor-kB (NF-kB) and decreasing nuclear translocation of the glyceraldehyde-3-phosphate dehydrogenase (GAPDH)/Siah1 complex. CB1, Cannabinoid receptor 1; CB2, cannabinoid receptor 2; IkBα, inhibitory kBα; iNOS, inducible nitric oxide synthase; ROS, reactive oxygen species. The Journal of Thoracic and Cardiovascular Surgery DOI: (10.1016/j.jtcvs.2018.07.083) Copyright © 2018 Terms and Conditions

Igor E. Konstantinov, MD, PhD, FRACS, and Tyson A Igor E. Konstantinov, MD, PhD, FRACS, and Tyson A. Fricke, MBBS, BMedSci The Journal of Thoracic and Cardiovascular Surgery DOI: (10.1016/j.jtcvs.2018.07.083) Copyright © 2018 Terms and Conditions