Fig. 6. C3 deficiency resulted in partial sparing of neuron loss in hippocampal CA3 in 16-month-old APP/PS1 mice. C3 deficiency resulted in partial sparing.

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* Figure A in S1 File Body weight (g) n=8/group

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Volume 16, Issue 6, Pages (August 2016)

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Fig. 6. C3 deficiency resulted in partial sparing of neuron loss in hippocampal CA3 in 16-month-old APP/PS1 mice. C3 deficiency resulted in partial sparing of neuron loss in hippocampal CA3 in 16-month-old APP/PS1 mice. (A) NeuN immunoreactivity in hippocampal CA3, CA1, and dentate gyrus (DG) and prefrontal cortex (PFC) regions in APP/PS1 and APP/PS1;C3 KO mice. Scale bars, 50 μm. (B) APP/PS1;C3 KO mice had more neurons in hippocampal CA3 compared to APP/PS1 mice (*P < 0.05, unpaired t test). (C to E) No significant differences were observed in neuron numbers in CA1, dentate gyrus, and PFC between APP/PS1 and APP/PS1;C3 KO mice. (F) Age-dependent neuron loss was observed between P30 and 16 months of age in WT and APP/PS1 mice and also between 4 and 16 months of age in APP/PS1 mice. However, neuron loss was not observed in C3 KO or APP/PS1;C3 KO mice (*P < 0.05, **P < 0.01, two-way ANOVA and Bonferroni post hoc test; n = 6 to 8; six equidistant planes, 150 μm apart). Qiaoqiao Shi et al., Sci Transl Med 2017;9:eaaf6295 Published by AAAS