Low concentration of circulating antimüllerian hormone is not predictive of reduced fecundability in young healthy women: a prospective cohort study

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Presentation transcript:

Low concentration of circulating antimüllerian hormone is not predictive of reduced fecundability in young healthy women: a prospective cohort study Casper P. Hagen, M.D., Sonja Vestergaard, Ph.D., Anders Juul, Dm.S.C., Niels Erik Skakkebæk, Dm.S.C., Anna-Maria Andersson, Ph.D., Katharina M. Main, Ph.D., Niels Henrik Hjøllund, Ph.D., Erik Ernst, Ph.D., Jens Peter Bonde, Dm.S.C., Richard A. Anderson, Ph.D., Tina Kold Jensen, Ph.D. Fertility and Sterility Volume 98, Issue 6, Pages 1602-1608.e2 (December 2012) DOI: 10.1016/j.fertnstert.2012.08.008 Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 1 (A) Kaplan-Meier curves showing cumulative proportion of pregnancy by serum level of antimüllerian hormone (AMH). Low AMH (quintile 1) orange line, medium AMH (quintiles 2–4) black line, high AMH (quintile 5) red line. P value describes difference between curves (log-rank test); P=.289. (B) Antimüllerian hormone level as a function of age in 186 participating women. Colors correspond to subgroups of AMH levels: low (orange), medium (black), and high (red). Fertility and Sterility 2012 98, 1602-1608.e2DOI: (10.1016/j.fertnstert.2012.08.008) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 (A) LH (IU/L), (B) FSH (IU/L), and (C) LH:FSH ratio in women with low antimüllerian hormone (AMH) (quintile 1, n = 32), medium AMH (quintiles 2–4, n = 96), and high AMH (quintile 5, n = 30). Left, hormone levels as a function of age. Orange triangles, low AMH levels; black triangles, medium AMH levels; red triangles, high AMH levels; black lines, geometric mean ± 1.96 SD, previously published (41). Right, boxplot of log10-transformed hormone levels indicating median (fat line), 25th–75th percentile (box) and 2.5th–97.5th percentile (hinges). Arrow indicates a serum value below the chosen scale of y-axis. P values indicate level of significance (independent sample t-tests, low vs. medium and medium vs. high, LH, FSH, and LH:FSH ratio: P=.409, P=.017; P=.027, P=.328; P=.114, P=.016, respectively). Fertility and Sterility 2012 98, 1602-1608.e2DOI: (10.1016/j.fertnstert.2012.08.008) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 (A) T (nmol/L), (B) sex hormone-binding globulin (SHBG; nmol/L), and (C) free androgen index in women with low antimüllerian hormone (AMH) (quintile 1, n = 32), medium AMH (quintiles 2–4, n = 96), and high AMH (quintile 5, n = 30). Left, hormone levels as a function of age. Orange triangles, low AMH levels; black triangles, medium AMH levels; red triangles, high AMH levels. Right, boxplot of log10-transformed hormone levels indicating median (fat line), 25th–75th percentile (box), and 2.5th–97.5th percentile (hinges). Arrow indicates a serum value above the chosen scale of y-axis. P values indicate level of significance (independent sample t-tests, low vs. medium, and medium vs. high, T, SHBG, and free androgen index: P=.230, P=.069; P=.031, P=.558; P=.013, P=.102, respectively). Fertility and Sterility 2012 98, 1602-1608.e2DOI: (10.1016/j.fertnstert.2012.08.008) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions