Fig. 2. Bestatin treatment improves tail anatomy and restores lymphatic function. Bestatin treatment improves tail anatomy and restores lymphatic function.

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Fig. 2. Bestatin treatment improves tail anatomy and restores lymphatic function. Bestatin treatment improves tail anatomy and restores lymphatic function. (A) Representative histology of mouse tail harvested on day 24 comparing samples from sham surgery control (sham) and animals treated with saline or bestatin after lymphatic ablation surgery (lymphatic surgery). Yellow arrowheads point at lymphatic dilation. Cutaneous dimension is indicated by yellow arrows. Scale bar, 200 μm; n = 6. (B) Fluorescence dextran microlymphangiography in the Prox1-Cre-ERT2-tdTomato mouse tail. Lymphatics are genetically marked by tdTomato (red) and outlined with a white dashed line. Fluorescein isothiocyanate (FITC)–dextran is shown in green. FITC-dextran not taken up by lymphatics is indicated by a white asterisk. Scale bar, 100 μm; n = 5. (C) Representative still photographs from movies S2 and S3 captured by a near-infrared (NIR) imaging system with a controlled pressure cuff. The collecting lymphatic function was tracked by imaging the transportation of a NIR dye in the vessels. Collecting lymphatics and the surgical wound are marked. Direction of lymph flow from the distal to the proximal part of the mouse tail is indicated. Scale bar, 500 μm; n = 3. (D) Trafficking ability of collecting lymphatics as quantified by the rate of NIR packet movement; n = 3; data are presented as means and SEM, Mann-Whitney test. (E) Representative images showing extravasation of Evans Blue dye from the lymphatics distal to the wound in the saline-treated mouse tail after lymphatic surgery; n = 3. Wen Tian et al., Sci Transl Med 2017;9:eaal3920 Published by AAAS