Safety and feasibility of near-infrared image-guided lymphatic mapping of regional lymph nodes in esophageal cancer Krista J. Hachey, MD, Denis M. Gilmore,

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Presentation transcript:

Safety and feasibility of near-infrared image-guided lymphatic mapping of regional lymph nodes in esophageal cancer Krista J. Hachey, MD, Denis M. Gilmore, MD, Katherine W. Armstrong, MPH, Sean E. Harris, MA, Jason L. Hornick, MD, PhD, Yolonda L. Colson, MD, PhD, Jon O. Wee, MD The Journal of Thoracic and Cardiovascular Surgery Volume 152, Issue 2, Pages 546-554 (August 2016) DOI: 10.1016/j.jtcvs.2016.04.025 Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Intraoperative NIR imaging protocol for lymphatic mapping in esophageal cancer. ICG, Indocyanine green; NIR, near-infrared; VATS, video-assisted thorascopic surgery; LN, lymph node. The Journal of Thoracic and Cardiovascular Surgery 2016 152, 546-554DOI: (10.1016/j.jtcvs.2016.04.025) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Submucosal esophageal ICG injection approach resulting in ICG dye migration through submucosal lymphatics (dark-blue line) and to more distal regional LNs (black line). ICG, Indocyanine green. The Journal of Thoracic and Cardiovascular Surgery 2016 152, 546-554DOI: (10.1016/j.jtcvs.2016.04.025) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 In vivo and ex vivo NIR image-guided identification of intra-abdominal esophageal LNs. A, In vivo NIR+ left periesophageal LN. B, NIR+ lymphatic tract to LN. C, Ex vivo confirmation of an NIR+ LN. The Journal of Thoracic and Cardiovascular Surgery 2016 152, 546-554DOI: (10.1016/j.jtcvs.2016.04.025) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Distribution of NIR+ LNs in the study patients displayed by anatomic nodal station. NIR+, Detection of near-infrared fluorescence; LN, lymph node. The Journal of Thoracic and Cardiovascular Surgery 2016 152, 546-554DOI: (10.1016/j.jtcvs.2016.04.025) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Video 1 Intraoperative near-infrared image–guided technique for regional node identification in esophageal cancer. Video available at http://www.jtcvsonline.org/article/S0022-5223(16)30083-6/addons. The Journal of Thoracic and Cardiovascular Surgery 2016 152, 546-554DOI: (10.1016/j.jtcvs.2016.04.025) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

NIR-guided in vivo regional esophageal LN detection. The Journal of Thoracic and Cardiovascular Surgery 2016 152, 546-554DOI: (10.1016/j.jtcvs.2016.04.025) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions