Cell Communication (Signaling) Part 2

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Presentation transcript:

Cell Communication (Signaling) Part 2 AP Biology Cell Communication (Signaling) Part 2

Phosphorylation and Hydrolysis

Receptor Protein

G protein Receptor

Tyrosine – Kinase Receptor

Ion Channel Receptors Signal molecule (ligand) Gate closed Ions Plasma membrane Ligand-gated ion channel receptor Gate open Cellular response Gate closed

Intracellular receptors

Secondary Messenger cAMP Adenylyl cyclase Phosphodiesterase Pyrophosphate H2O P P i ATP Cyclic AMP AMP

First messenger (signal molecule such as epinephrine) Adenylyl cyclase G protein G-protein-linked receptor GTP ATP Second messenger cAMP Protein kinase A Cellular responses

Secondary Messenger Calmodulin EXTRACELLULAR FLUID Signal molecule (first messenger) G protein DAG GTP G-protein-linked receptor PIP2 Phospholipase C IP3 (second messenger) IP3-gated calcium channel Cellular re- sponses Various proteins activated Endoplasmic reticulum (ER) Ca2+ Ca2+ (second messenger) CYTOSOL

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