Suppressing NFAT Increases VEGF Signaling in Hemangiomas

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Suppressing NFAT Increases VEGF Signaling in Hemangiomas Lisette M. Acevedo, David A. Cheresh Cancer Cell Volume 14, Issue 6, Pages 429-430 (December 2008) DOI: 10.1016/j.ccr.2008.11.009 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 TEM8 and VEGFR2 Can Negatively Regulate β1 Integrin-Mediated NFAT-Dependent VEGFR1 Expression through Complex Formation In normal endothelial cells (ECs), β1 integrin activation leads to NFAT-dependent transcription of FLT1 (VEGFR1), the VEGF decoy receptor. However, this pathway can be dampened by complex formation between β1 integrin, VEGFR2, and TEM8. In hemangioma ECs (hemECs), constitutive VEGF signaling may be due to enhanced complex formation in hemECs versus normal ECs, which then leads to decreased FLT1 transcription. Cancer Cell 2008 14, 429-430DOI: (10.1016/j.ccr.2008.11.009) Copyright © 2008 Elsevier Inc. Terms and Conditions