Defining Disease Severity in Inflammatory Bowel Diseases: Current and Future Directions  Laurent Peyrin-Biroulet, Julián Panés, William J. Sandborn, Séverine Vermeire, Silvio Danese, Brian G. Feagan, Jean-Frédéric Colombel, Stephen B. Hanauer, Beth Rycroft  Clinical Gastroenterology and Hepatology  Volume 14, Issue 3, Pages 348-354.e17 (March 2016) DOI: 10.1016/j.cgh.2015.06.001 Copyright © 2016 AGA Institute Terms and Conditions

Figure 1 The interplay between the different domains that govern disease severity. (A) When discussing disease severity in IBD, it is important to consider the impact of disease on the patient, disease burden, and disease course. However, these measures are not mutually exclusive and the correlations and interactions between them are not necessarily proportionate. (B) Example of interplay between domains in a hypothetical patient with asymptomatic extensive small-bowel CD and moderately active endoscopic lesions. (C) Example of interplay between domains in a hypothetical patient with an isolated, short ileal stricture associated with disabling obstructive symptoms. GI, gastrointestinal. *Only for Crohn’s disease. Clinical Gastroenterology and Hepatology 2016 14, 348-354.e17DOI: (10.1016/j.cgh.2015.06.001) Copyright © 2016 AGA Institute Terms and Conditions