Volume 124, Issue 4, Pages (April 2003)

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Volume 124, Issue 4, Pages 1010-1019 (April 2003) Angiotensin-converting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats Atsushi Kuno, Tamaki Yamada, Kazuhiko Masuda, Kumiko Ogawa, Mitsue Sogawa, Soichi Nakamura, Takahiro Nakazawa, Hirotaka Ohara, Tomoyuki Nomura, Takashi Joh, Tomoyuki Shirai, Makoto Itoh Gastroenterology Volume 124, Issue 4, Pages 1010-1019 (April 2003) DOI: 10.1053/gast.2003.50147 Copyright © 2003 American Gastroenterological Association Terms and Conditions

Fig. 1 Gross appearance of the pancreas in the (A) untreated and (B) high-dose lisinopril groups. (A) The pancreas is severely atrophic and contains widely spread brown and red foci. (B) The pancreas has an almost intact appearance. Gastroenterology 2003 124, 1010-1019DOI: (10.1053/gast.2003.50147) Copyright © 2003 American Gastroenterological Association Terms and Conditions

Fig. 2 Representative histologic appearance of the pancreas in the untreated (A, B) and high-dose lisinopril (C, D) groups (A, C: H&E staining; B, D: Azan staining 400×). Untreated group. (A) Medium infiltration of neutrophils, lymphocytes, and plasma cells, disappearance of acinar cells and replacement with fibrous tissue are evident. This view shows a score of 2 for inflammatory cell infiltration, edema, and fibrosis, and a score of 1 for acinar cell necrosis and hemorrhage. (B) Fine to thick collagen fiber is stained in blue. High-dose lisinopril group. (C) Focal inflammatory changes are observed slightly around the duct. This view shows a score of 1 for inflammation and fibrosis and 0 for other categories. (D) Fine collagen fiber is seen between acinar. Gastroenterology 2003 124, 1010-1019DOI: (10.1053/gast.2003.50147) Copyright © 2003 American Gastroenterological Association Terms and Conditions

Fig. 3 Expression of TGF-β1 mRNA analyzed by RT-PCR in the untreated and high-dose lisinopril groups and 20-week-old male Wistar rats. The β-actin mRNA is expressed in each pancreatic tissue as an internal control. Gastroenterology 2003 124, 1010-1019DOI: (10.1053/gast.2003.50147) Copyright © 2003 American Gastroenterological Association Terms and Conditions

Fig. 4 Immunohistochemical staining for α-SMA in the pancreas in the (A) untreated and (B, C) high-dose lisinopril groups (×400). (A) α-SMA-positive cells with the stellate morphology (activated PSCs) were present in the peri-acinar fibrotic areas and vascular walls. This view shows all scores of 1 but a score of 2 for fibrosis. (B) α-SMA-positive cells were present only in the vascular walls in most of the specimens. This view shows scores of 0 for all categories. (C) α-SMA-positive cells barely were observed in the periductal areas. This view shows scores of 1 for fibrosis and inflammation and 0 for other categories. Gastroenterology 2003 124, 1010-1019DOI: (10.1053/gast.2003.50147) Copyright © 2003 American Gastroenterological Association Terms and Conditions