Volume 14, Issue 12, Pages 1171-1181 (December 2015) Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer's Disease (DOMINO-AD) trial: secondary and post-hoc analyses  Prof Robert Howard, MD, Rupert McShane, MD, Prof James Lindesay, DM, Craig Ritchie, MD, Ashley Baldwin, FRCPsych, Robert Barber, MD, Prof Alistair Burns, MD, Prof Tom Dening, FRCPsych, David Findlay, FRCPsych, Prof Clive Holmes, FRCPsych, Prof Robert Jones, FRCPsych, Prof Roy Jones, FRCP, Prof Ian McKeith, FMedSci, Ajay Macharouthu, MRCPsych, Prof John O'Brien, DM, Bart Sheehan, MD, Edmund Juszczak, MSc, Prof Cornelius Katona, MD, Prof Robert Hills, DPhil, Prof Martin Knapp, PhD, Prof Clive Ballard, MD, Prof Richard G Brown, PhD, Prof Sube Banerjee, MD, Jessica Adams, BSc, Tony Johnson, PhD, Peter Bentham, MMedSc, Patrick P J Phillips, PhD  The Lancet Neurology  Volume 14, Issue 12, Pages 1171-1181 (December 2015) DOI: 10.1016/S1474-4422(15)00258-6 Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 1 Trial profile NHP=nursing home placement. SMMSE=Standardised Mini-Mental State Examination. The Lancet Neurology 2015 14, 1171-1181DOI: (10.1016/S1474-4422(15)00258-6) Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 2 Kaplan-Meier curves of cumulative probability of nursing home placement by (A) treatment group, (B) continuation versus discontinuation of donepezil, and (C) addition of memantine HR=hazard ratio. NHP=nursing home placement. The Lancet Neurology 2015 14, 1171-1181DOI: (10.1016/S1474-4422(15)00258-6) Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 3 Comparison of the effect of discontinuation with continuation of donepezil on risk of nursing home placement in each category of randomisation minimisation strata and time period from randomisation Data are n (%)/N or event rate ratio (95% CI). Error bars are 95% CIs. The dashed line shows the estimate of the unstratified event rate ratio. The comparison of the effect of memantine is not shown because we noted no overall difference on event rate, stratified or unstratified. SMMSE=Standardised Mini-Mental State Examination. *Difference between observed and expected events within each stratum; this is the log-rank statistic. †All excluding time from randomisation. The Lancet Neurology 2015 14, 1171-1181DOI: (10.1016/S1474-4422(15)00258-6) Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 4 Change in risk of nursing home placement with time (A) Fitted hazard and (B) cumulative probability of nursing home placement for the flexible parametric survival model. Solid lines show fitted estimates and the dashed lines in (B) show Kaplan-Meier non-parametric estimates. Shaded areas show 95% CIs. This post-hoc analysis shows how the hazard (instantaneous risk) of NHP changes with time. NHP=nursing home placement. The Lancet Neurology 2015 14, 1171-1181DOI: (10.1016/S1474-4422(15)00258-6) Copyright © 2015 Elsevier Ltd Terms and Conditions