RNA Interference in Mammals: The Virus Strikes Back

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RNA Interference in Mammals: The Virus Strikes Back Bryan R. Cullen Immunity Volume 46, Issue 6, Pages 970-972 (June 2017) DOI: 10.1016/j.immuni.2017.05.004 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Inhibition of RNAi by Viral Suppressors of RNA Interference Qiu et al. (2017) propose that infection of cells by WT viruses results in the production of viral suppressors of RNA interference (VSR) proteins—A3, in the case of HEV71—that bind the dsRNA replication intermediate and block access by Dicer. In contrast, in the absence of the VSR, Dicer is able to access the dsRNA intermediate and cleave the dsRNA from the termini to generate vsiRNAs that inhibit viral replication. RdRP, viral RNA-dependent RNA polymerase. Immunity 2017 46, 970-972DOI: (10.1016/j.immuni.2017.05.004) Copyright © 2017 Elsevier Inc. Terms and Conditions