High specificity and sensitivity of NRAS Q61R immunohistochemistry (IHC) in melanomas Pierre-Alexandre Just, MD, PhD, Christelle Pouliquen, MD, Anne.

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High specificity and sensitivity of NRAS Q61R immunohistochemistry (IHC) in melanomas Pierre-Alexandre Just, MD, PhD, Christelle Pouliquen, MD, Anne Audebourg, Dr-Ing, Sara Laurent-Roussel, MD, Agnès Carlotti, MD, Nicolas Dupin, MD, PhD, Marie-Cécile Vacher-Lavenu, MD, PhD, Michel Vidaud, PharmD, PhD, Benoît Terris, MD, PhD, Eric Pasmant, PharmD, PhD Journal of the American Academy of Dermatology Volume 74, Issue 3, Pages 572-573 (March 2016) DOI: 10.1016/j.jaad.2015.11.011 Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 A, Melanoma with NRAS Q61R mutation: anti-NRAS Q61R immunohistochemistry (IHC). Note strong and diffuse cytoplasmic staining of tumor cells and the nonspecific staining of endothelial cells. B, Melanoma without NRAS Q61R mutation: anti-NRAS Q61R IHC. Note the nonspecific staining of endothelial cells and the absence of staining in tumor cells. Journal of the American Academy of Dermatology 2016 74, 572-573DOI: (10.1016/j.jaad.2015.11.011) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions