Eun-Jung Jung, George A. Calin  Cancer Cell 

Slides:



Advertisements
Similar presentations
Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.
Advertisements

Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation Silvia Di Agostino,
Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.
The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells Jenny M. Karo, David G. Schatz, Joseph C. Sun Cell Volume.
Genetic and Epigenetic Silencing of MicroRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression María J. Bueno, Ignacio Pérez de Castro, Marta Gómez de.
What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell
Origins of Metastatic Traits Sakari Vanharanta, Joan Massagué Cancer Cell Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr
Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni
Transcriptional Control of Gene Expression by MicroRNAs Basel Khraiwesh, M. Asif Arif, Gotelinde I. Seumel, Stephan Ossowski, Detlef Weigel, Ralf Reski,
Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells Nilay Sethi, Xudong Dai, Christopher.
Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell
C/EBPβ at the core of the TGFβ cytostatic response and its evasion in metastatic breast cancer cells Roger R. Gomis, Claudio Alarcón, Cristina Nadal, Catherine.
Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)
Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem
ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics Carlos L. Arteaga, Jeffrey A. Engelman Cancer Cell Volume.
Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia Tim C.P. Somervaille, Michael L. Cleary Cancer Cell.
The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.
IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.
Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.
Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity Cai-Hong.
The Mitochondrial Basis of Aging Nuo Sun, Richard J. Youle, Toren Finkel Molecular Cell Volume 61, Issue 5, Pages (March 2016) DOI: /j.molcel
Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung Zvi Granot, Erik Henke, Elizabeth A. Comen, Tari A. King, Larry Norton, Robert Benezra.
Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.
A Conditional Mouse Model of Synovial Sarcoma: Insights into a Myogenic Origin Malay Haldar, Jeffrey D. Hancock, Cheryl M. Coffin, Stephen L. Lessnick,
The Kinase-Independent, Second Life of CDK6 in Transcription
Man's Best Friend: Utilizing Naturally Occurring Tumors in Dogs to Improve Chimeric Antigen Receptor T-cell Therapy for Human Cancers  Melinda Mata, Stephen.
We Contain Multitudes: The Protean Face of Retinoblastoma
Linking miRNA Regulation to BCR-ABL Expression: The Next Dimension
The Metastasis Problem Gets Stickier
Warren S. Pear, M. Celeste Simon  Cancer Cell 
Metastasis gets site specific
Chiranjib Chakraborty, Ashish Ranjan Sharma, Garima Sharma, C
Accelerating drug discovery: Open source cancer cell biology?
PI3K Regulatory Subunits Lose Control in Cancer
HSF1 in Translation Cancer Cell
Volume 9, Issue 6, Pages (June 2006)
Tumor Evolution: A Problem of Histocompatibility
Actin and Microtubules: Working Together to Control Spindle Polarity
Annapoorni Rangarajan, Sue J. Hong, Annie Gifford, Robert A. Weinberg 
MDS Is a Stem Cell Disorder After All
DAISY: Picking Synthetic Lethals from Cancer Genomes
The Wind God Promotes Lung Cancer
A Radical Role for p38 MAPK in Tumor Initiation
Volume 9, Issue 6, Pages (June 2006)
Stem Cell Therapies in Clinical Trials: Progress and Challenges
PICS-ure This: Prosenescence Therapy?
Volume 131, Issue 1, Pages (October 2007)
MicroRNA Regulation of Stem Cell Fate
How To Choose a Good Scientific Problem
Hopping between Differentiation States in Lung Adenocarcinoma
MicroRNAs and Parallel Stem Cell Lives
The p27Kip1 tumor suppressor gene: Still a suspect or proven guilty?
David A. Tuveson, John P. Neoptolemos  Cell 
Volume 9, Issue 3, Pages (March 2006)
FAL1ing inside an Amplicon
MicroRNAs and Viral Infection
Volume 130, Issue 6, (September 2007)
Amino Acid Signaling to TOR Activation: Vam6 Functioning as a Gtr1 GEF
MicroRNA-155 Function in B Cells
Marta Chesi, P. Leif Bergsagel  Cancer Cell 
To Infinium, and Beyond! Cancer Cell
FAL1ing inside an Amplicon
Volume 10, Issue 3, Pages (September 2006)
How To Choose a Good Scientific Problem
There's a Time and a Place for MYCN
Volume 134, Issue 6, (September 2008)
David Hubel and Torsten Wiesel
Volume 12, Issue 6, Pages (December 2007)
Targeting Protein Stability with a Small Molecule
Presentation transcript:

The Meaning of 21 in the MicroRNA World: Perfection Rather than Destruction?  Eun-Jung Jung, George A. Calin  Cancer Cell  Volume 18, Issue 3, Pages 203-205 (September 2010) DOI: 10.1016/j.ccr.2010.08.015 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 The Molecular Mechanism Involving miR-21 and the Clinical Significance of miR-21 Overexpression in Lung Cancers The left panel represents the complex mechanism reported by Hatley and colleagues (“the perfection” of miR-21 function), whereas the right panel indicates the main clinical applications (that transform miR-21 “destructive” potential to a clinically useful potential). The gene names are as provided in the NCBI database at http://www.ncbi.nlm.nih.gov/gene. Cancer Cell 2010 18, 203-205DOI: (10.1016/j.ccr.2010.08.015) Copyright © 2010 Elsevier Inc. Terms and Conditions