Volume 67, Issue 6, Pages (June 2015)

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Volume 67, Issue 6, Pages 1122-1133 (June 2015) A Systematic Review and Meta-analysis of Clinicopathologic Factors Linked to Intravesical Recurrence After Radical Nephroureterectomy to Treat Upper Tract Urothelial Carcinoma Thomas Seisen, Benjamin Granger, Pierre Colin, Priscilla Léon, Guillemette Utard, Raphaële Renard-Penna, Eva Compérat, Pierre Mozer, Olivier Cussenot, Shahrokh F. Shariat, Morgan Rouprêt European Urology Volume 67, Issue 6, Pages 1122-1133 (June 2015) DOI: 10.1016/j.eururo.2014.11.035 Copyright © 2014 European Association of Urology Terms and Conditions

Fig. 1 Preferred reporting items for systematic reviews and meta-analysis (PRISMA) flow chart. European Urology 2015 67, 1122-1133DOI: (10.1016/j.eururo.2014.11.035) Copyright © 2014 European Association of Urology Terms and Conditions

Fig. 2 Forrest plots of meta-analyses of patient-specific predictors of IVR: (A) age, (B) male gender, (C) previous bladder cancer, (D) preoperative chronic kidney disease, and (E) preoperative hydronephrosis. IVR=intravesical recurrence PE=predictor effect; sePE=standard error of the predictor effect. European Urology 2015 67, 1122-1133DOI: (10.1016/j.eururo.2014.11.035) Copyright © 2014 European Association of Urology Terms and Conditions

Fig. 3 Forrest plots of meta-analyses of tumor-specific predictors of IVR: (A) positive preoperative urinary cytology, (B) ureteral tumor location, (C) tumor multifocality, (D) tumor size, (E) invasive pT stage, (F) pN+ stage, (G) low grade, (H) concomitant carcinoma in situ, (I) lymphovascular-invasion, and (J) tumor necrosis. IVR=intravesical recurrence PE=predictor effect; sePE=standard error of the predictor effect. European Urology 2015 67, 1122-1133DOI: (10.1016/j.eururo.2014.11.035) Copyright © 2014 European Association of Urology Terms and Conditions

Fig. 3 Forrest plots of meta-analyses of tumor-specific predictors of IVR: (A) positive preoperative urinary cytology, (B) ureteral tumor location, (C) tumor multifocality, (D) tumor size, (E) invasive pT stage, (F) pN+ stage, (G) low grade, (H) concomitant carcinoma in situ, (I) lymphovascular-invasion, and (J) tumor necrosis. IVR=intravesical recurrence PE=predictor effect; sePE=standard error of the predictor effect. European Urology 2015 67, 1122-1133DOI: (10.1016/j.eururo.2014.11.035) Copyright © 2014 European Association of Urology Terms and Conditions

Fig. 4 Forrest plots of meta-analyses of treatment-specific predictors of IVR: (A) laparoscopic surgical approach, (B) endoscopic bladder cuff removal, (C) extravesical bladder cuff removal, (D) positive surgical margins, and (E) adjuvant chemotherapy. IVR=intravesical recurrence PE=predictor effect; sePE=standard error of the predictor effect. European Urology 2015 67, 1122-1133DOI: (10.1016/j.eururo.2014.11.035) Copyright © 2014 European Association of Urology Terms and Conditions