Volume 115, Issue 5, Pages (November 1998)

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Volume 115, Issue 5, Pages 1113-1122 (November 1998) Lack of correlation between Lewis antigen expression by Helicobacter pylori and gastric epithelial cells in infected patients Diane E. Taylor, David A. Rasko, Richard Sherburne, Clinton Ho, Laurence D. Jewell Gastroenterology Volume 115, Issue 5, Pages 1113-1122 (November 1998) DOI: 10.1016/S0016-5085(98)70082-4 Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 1 Structures of type 1 and type 2 Le carbohydrate structures. The enzymes required for generation of these structures are as shown next to the arrows and are α1→4-fucosyltransferase (Lea and Leb), α1→3-fucosyltransferase (Lex and Ley), and α1→2-fucosyltransferase (Leb and Ley). Gastroenterology 1998 115, 1113-1122DOI: (10.1016/S0016-5085(98)70082-4) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 2 (A) Negative control (H. pylori–negative) in which the primary antibody in the reaction was replaced by mouse serum. Neither the superficial mucous cells nor the deep glands showed reactivity (original magnification 110×). (B) Anti-Leb staining of gastric epithelium with H. pylori–associated gastritis. The brown pigmentation indicates positive staining in the superficial mucous cells, deep glands, and luminal secretions. In the stroma, mixed inflammatory cells are evident (original magnification 110×). (C) Anti-Lea staining of gastric epithelium with H. pylori–associated gastritis. The brown pigmentation indicates positive staining in the superficial mucous cells and luminal secretions. In the stroma, mixed inflammatory cells are evident (original magnification 275×). (D) Anti-Lea staining of gastric epithelium with H. pylori–associated gastritis. The brown pigmentation indicates positive staining in the superficial mucous cells, deep glands, and luminal secretions. In the stroma, mixed inflammatory cells are evident (original magnification 440×). (E) Anti-Lex staining of gastric epithelium with H. pylori–associated gastritis. The brown pigmentation indicates positive staining in the superficial mucous cells, deep glands, and luminal secretions. In the stroma, mixed inflammatory cells are evident (original magnification 110×). (F) Anti-Ley staining of gastric epithelium with H. pylori–associated gastritis. The brown pigmentation indicates positive staining in the superficial mucous cells, deep glands, and luminal secretions. In the stroma, mixed inflammatory cells are evident (original magnification 110×). Gastroenterology 1998 115, 1113-1122DOI: (10.1016/S0016-5085(98)70082-4) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 3 Comparison of degree of expression of Lex and Ley by 24 H. pylori strains determined by ELISA. The black bars represent cagA+ strains and the white bars cagA− strains. Gastroenterology 1998 115, 1113-1122DOI: (10.1016/S0016-5085(98)70082-4) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 4 Expression of Lex vs. Ley by 24 H. pylori strains. Squares represent cagA− strains, whereas the rest are cagA+ strains. Gastroenterology 1998 115, 1113-1122DOI: (10.1016/S0016-5085(98)70082-4) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 5 Immunoelectron microscopy of gastric biopsy S93-12291 showing reactivity with Lex (20-nm gold particles) and with Ley (10-nm gold particles) expressed by gastric epithelial cells (bar = 1 μm). Gastroenterology 1998 115, 1113-1122DOI: (10.1016/S0016-5085(98)70082-4) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 6 Immunoelectron microscopy of whole cells of H. pylori UA1182 cultured from biopsy S93-12291 showing reactivity with Lex (20-nm gold particles) and with Ley (10-nm gold particles). Gastroenterology 1998 115, 1113-1122DOI: (10.1016/S0016-5085(98)70082-4) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 7 Immunoelectron microscopy of biopsy S93-12291 showing an adhesion pedestal formation between gastric epithelial tissue and an H. pylori UA1182 cell. The Lex structures labeled are on both epithelial tissue and H. pylori (bar = 0.5 μm). Gastroenterology 1998 115, 1113-1122DOI: (10.1016/S0016-5085(98)70082-4) Copyright © 1998 American Gastroenterological Association Terms and Conditions