Volume 154, Issue 8, Pages 2111-2121.e8 (June 2018) Baseline Factors Associated With Improvements in Decompensated Cirrhosis After Direct-Acting Antiviral Therapy for Hepatitis C Virus Infection  Omar El-Sherif, Z. Gordon Jiang, Elliot B. Tapper, K.C. Huang, Alex Zhong, Anu Osinusi, Michael Charlton, Michael Manns, Nezam H. Afdhal, Kenneth Mukamal, John McHutchison, Diana M. Brainard, Norah Terrault, Michael P. Curry  Gastroenterology  Volume 154, Issue 8, Pages 2111-2121.e8 (June 2018) DOI: 10.1053/j.gastro.2018.03.022 Copyright © 2018 AGA Institute Terms and Conditions

Gastroenterology 2018 154, 2111-2121. e8DOI: (10. 1053/j. gastro. 2018 Copyright © 2018 AGA Institute Terms and Conditions

Figure 1 Outcome of DAA treatment among patients with CPT B and C cirrhosis. (A) Change in CPT class from baseline to week 36 from the start of DAA therapy. (B) Kaplan–Meier curves of achieving a CPT A status were plotted for those with or without SVR12 in black and gray solid lines, respectively. Dashed lines represent 95% CI. P value calculated by Cox proportional hazard regression right-censored at 36 weeks. Gastroenterology 2018 154, 2111-2121.e8DOI: (10.1053/j.gastro.2018.03.022) Copyright © 2018 AGA Institute Terms and Conditions

Figure 2 MELD purgatory before and after DAA treatment. The MELD and CPT scores of each patients in the clinical trials were plotted before the DAA treatment (A) and at the last follow-up (B). MELD purgatory was defined as CPT B or C (score ≥7) and MELD score ≤14 (Zone 4 on the MELD/CPT plot). Each open circle represents 1 or more patient with the corresponding MELD and CPT scores. The number of observations in each zone was indicated in each quadrant. Gastroenterology 2018 154, 2111-2121.e8DOI: (10.1053/j.gastro.2018.03.022) Copyright © 2018 AGA Institute Terms and Conditions

Figure 3 Kaplan Meier curves of achieving CPT A and death/transplant with BE3A score. Kaplan-Meier curves of different BE3A categories were plotted for achieving a CPT A status (A) and death or liver transplantation (B). Dashed lines represent 95% CI. Number of observations at 0, 10, 20, and 30 weeks were shown below each panel. Gastroenterology 2018 154, 2111-2121.e8DOI: (10.1053/j.gastro.2018.03.022) Copyright © 2018 AGA Institute Terms and Conditions

Supplementary Figure 1 Impact of SVR on death and liver transplantation. Kaplan–Meier curves of death or liver transplantation were plotted for those with or without SVR12 in black and gray solid lines, respectively. Individual deaths or liver transplantation before SVR12 are included in (A), but excluded in (B). Dashed lines represent 95% CI. P value calculated by Cox proportional hazard regression right-censored at 40 weeks. Gastroenterology 2018 154, 2111-2121.e8DOI: (10.1053/j.gastro.2018.03.022) Copyright © 2018 AGA Institute Terms and Conditions

Supplementary Figure 2 Comparison of BE3A score with alternative models. The performance of the BE3A model was compared to 2 alternative modeling strategies. Model 1 used continuous variables of ALT, albumin and BMI; while Model 2 used the same binary variables as the BE3A. Model 1 and Model 2 used multivariate logistic regression in comparison to the BE3A model where a univariate 0–5 point score was used. Gastroenterology 2018 154, 2111-2121.e8DOI: (10.1053/j.gastro.2018.03.022) Copyright © 2018 AGA Institute Terms and Conditions

Supplementary Figure 3 Bootstrap validation of BE3A score and BE3A calculator. The performance of BE3A score (A) and BE3A calculator (B) in predicting achieving CPT A, and the performance of BE3A calculator in predicting death or transplantation (C) was evaluated using parametric bootstrap ROC analysis. The distribution of AUC coefficient from 100 simulations was plotted in histograms. Gastroenterology 2018 154, 2111-2121.e8DOI: (10.1053/j.gastro.2018.03.022) Copyright © 2018 AGA Institute Terms and Conditions