Parkinson’s Disease: A Thalamostriatal Rebalancing Act?

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Parkinson’s Disease: A Thalamostriatal Rebalancing Act? Nicolas X. Tritsch, Adam G. Carter Neuron Volume 89, Issue 4, Pages 675-677 (February 2016) DOI: 10.1016/j.neuron.2016.02.008 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Synaptic Rewiring Dopamine depletion in a PD mouse model reduces the strength of thalamic inputs (orange), but not cortical inputs (green), onto dSPNs (red) compared to iSPNs (blue) in the striatum, unbalancing the “direct” and “indirect” pathways and thereby reducing movement. Neuron 2016 89, 675-677DOI: (10.1016/j.neuron.2016.02.008) Copyright © 2016 Elsevier Inc. Terms and Conditions