Volume 121, Issue 5, Pages 1109-1119 (November 2001) Cerebral metabolism of ammonia and amino acids in patients with fulminant hepatic failure  Gitte Irene Strauss, Gitte Moos Knudsen, Jens Kondrup, Kirsten Møller, Fin Stolze Larsen  Gastroenterology  Volume 121, Issue 5, Pages 1109-1119 (November 2001) DOI: 10.1053/gast.2001.29310 Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 1 (A) Relationship between the arterial and venous ammonia concentration showing the line of identity and the regression line (slope 0.75 ± 0.05 and is ≠ 1) for the cerebral ammonia extraction. (B) Scatterplot between arterial ammonia and net cerebral ammonia uptake in patients with FHF. Gastroenterology 2001 121, 1109-1119DOI: (10.1053/gast.2001.29310) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 2 The mean cerebral glutamine-nitrogen efflux in patients with FHF during normoventilation (I) and hyperventilation (II), in patients with cirrhosis of the liver and in healthy subjects (ANOVA on Ranks, P < 0.05). Dashed areas shows the maximal cerebral glutamine efflux (mean) that can be explained by cerebral ammonia uptake. Gastroenterology 2001 121, 1109-1119DOI: (10.1053/gast.2001.29310) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 3 Boxplot showing the median, 10th, 25th, 75th, and 90th percentiles as vertical boxes with error bar of arterial ammonia concentration (P = 0.002), net cerebral ammonia uptake (P = 0.02), and net cerebral glutamine efflux (P = 0.02) in survivors compared with nonsurvivors. Gastroenterology 2001 121, 1109-1119DOI: (10.1053/gast.2001.29310) Copyright © 2001 American Gastroenterological Association Terms and Conditions