Cell migration Current Biology Rick Horwitz, Donna Webb  Current Biology  Volume 13, Issue 19, Pages R756-R759 (September 2003) DOI: 10.1016/j.cub.2003.09.014

Figure 1 Migration in human health. Migration is central to many physiological and pathological processes. A better understanding of the factors that regulate migration could lead to novel therapeutic approaches and applications. Current Biology 2003 13, R756-R759DOI: (10.1016/j.cub.2003.09.014)

Figure 2 Steps of migration. Images of a human fibroblast expressing paxillin–GFP, captured by time-lapse fluorescence microscopy, illustrate the mechanics of migration. (A–C) Migration begins when a cell responds to an external signal that leads to the polarization and extension of a protrusion in the direction of movement. Adhesions form to attach the protrusion to the substratum (arrows). (D–F) Contraction then moves the cell body forward and the adhesions at the rear disassemble as the rear retracts. Current Biology 2003 13, R756-R759DOI: (10.1016/j.cub.2003.09.014)