Volume 53, Issue 4, Pages 1014-1021 (April 1998) Icodextrin with nitroprusside increases ultrafiltration and peritoneal transport during long CAPD dwells  Caroline E. Douma, M.D., Ph.D., Johan K. Hiralall, Dirk R. de Waart, Dirk G. Struijk, Raymond T. Krediet  Kidney International  Volume 53, Issue 4, Pages 1014-1021 (April 1998) DOI: 10.1111/j.1523-1755.1998.00821.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 The time course of the transcapillary ultrafiltration (▪), lymphatic absorption (▾) and the resulting change in intraperitoneal volume (▴) with 7.5% icodextrin dialysate (A) and after the addition of nitroprusside (B). *P≤ 0.05 and **P≤ 0.01 when compared to the icodextrin experiment without nitroprusside. Kidney International 1998 53, 1014-1021DOI: (10.1111/j.1523-1755.1998.00821.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 The restriction coefficient for macromolecules without (-) and with (▾) nitroprusside in relation to the time treated with CAPD. Each individual patient is represented by an arrow. The length of the arrow indicates the magnitude of the effect of nitroprusside on the restriction coefficient. The regression lines are based upon the relationship between the time treated with CAPD and the restriction coefficient with icodextrin (r = 0.7, P = 0.04) and the CAPD treatment time and the restriction coefficient with icodextrin and nitroprusside (r=-0.1, P = 0.70). Kidney International 1998 53, 1014-1021DOI: (10.1111/j.1523-1755.1998.00821.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 The relationship between the MTAC of creatinine and the increase in intraperitoneal volume by icodextrin after eight hours. The ▴ shows the same relationship after the addition of nitroprusside. Arrows are drawn from the value without nitroprusside to the value after the addition of nitroprusside for each individual patient. Kidney International 1998 53, 1014-1021DOI: (10.1111/j.1523-1755.1998.00821.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 4 Regression lines based upon the relationship between the median D/P ratios of urea, creatinine, urate and β2-microglobulin and their molecular weights (•). The positions of nitrate and cGMP (○) are given in relation to their molecular weight during various conditions. (A) Icodextrin at 240 minutes. (B) Icodextrin with nitroprusside at 240 minutes. (C) Icodextrin at 480 minutes. (D) Icodextrin with nitroprusside at 480 minutes. *P < 0.001 for increase in the observed D/P ratio cGMP with regard to the expected D/P ratio cGMP. Kidney International 1998 53, 1014-1021DOI: (10.1111/j.1523-1755.1998.00821.x) Copyright © 1998 International Society of Nephrology Terms and Conditions