Genes to Function to Therapeutics PROTEIN-PROTEIN INTERACTIONS Madhavi K. Ganapathiraju Associate Professor Department of Biomedical Informatics University of Pittsburgh madhavi@pitt.edu Faculty of Biomedical Informatics Training Program Intelligent Systems Program Joint CMU-Pitt Ph.D. Program in Comp Bio Language Technologies Institute (CMU) Informatics and Engineering for Biomedicine @ University of Pittsburgh

? Protein-Protein Interactions Theme of Research in Madhavi’s Lab Central to all biological processes and structural scaffolds The network is a medium for systems biology research But 90% of protein-protein interactions are unknown today ? ~22,500 protein-coding genes Human Interactome 200,000 to 600,000 PPIs protein-pairs ~250Million possible pairs Theme of Research in Madhavi’s Lab Discovery of protein-protein interactions from large data sources using Machine Learning methods Results: 1000’s of Novel PPIs discovered Accurately (c) Madhavi Ganapathiraju

Our work is focused on these 4 themes: Predict novel PPIs, Annotate and analyze PPIs for dissemination to biologists And engage biologists and computer scientists to translate the PPIs

Electronics and Communications Engg Recent Interests Electronics and Communications Engg Smart Lifestyle IoT Enabled Sensors for Health Stress Monitoring through Sensor Fusion (c) Madhavi Ganapathiraju