Volume 375, Issue 9732, Pages (June 2010)

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Volume 375, Issue 9732, Pages 2143-2151 (June 2010) Gene–environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study Dr Ruth C Travis, DPhil, Gillian K Reeves, PhD, Jane Green, MD, Diana Bull, Sarah J Tipper, MSc, Krys Baker, Prof Valerie Beral, FRS, Prof Richard Peto, FRS, Prof John Bell, FRS, Diana Zelenika, PhD, Prof Mark Lathrop, PhD The Lancet Volume 375, Issue 9732, Pages 2143-2151 (June 2010) DOI: 10.1016/S0140-6736(10)60636-8 Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 1 Summary of findings for 12 SNPs in 7610 women with breast cancer and 10 196 randomly selected controls without breast cancer The Lancet 2010 375, 2143-2151DOI: (10.1016/S0140-6736(10)60636-8) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 2 Distribution of environmental risk factors for breast cancer by genotype Figure shows means or proportions and 95% CIs. Numbers do not always add up because of missing values. *Never users of hormone replacement therapy. †Conventional p values are shown in the figure; all p values are non-significant after adjustment for multiple testing, apart from that for rs889132 by height, when adjusted p=0·01. †Insufficient data. The Lancet 2010 375, 2143-2151DOI: (10.1016/S0140-6736(10)60636-8) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 3 Per-allele relative risk (95% CI) of breast cancer by ten environmental risk factors for breast cancer Conventional p values are shown in the figure; all p values are non-significant after adjustment for multiple testing. HRT=hormone replacement therapy in postmenopausal women. *Never users of HRT. The Lancet 2010 375, 2143-2151DOI: (10.1016/S0140-6736(10)60636-8) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 4 Per-allele relative risk (95% CI) of oestrogen-receptor-positive breast cancer by use of hormone replacement therapy in postmenopausal women Conventional p values are shown in the figure; all p values are non-significant after adjustment for multiple testing. The Lancet 2010 375, 2143-2151DOI: (10.1016/S0140-6736(10)60636-8) Copyright © 2010 Elsevier Ltd Terms and Conditions