A 5-week-old HIV-1–exposed girl with failure to thrive and diffuse nodular pulmonary infiltrates  Filiz O Seeborg, MD, Mary E Paul, MD, Stuart L Abramson,

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Presentation transcript:

A 5-week-old HIV-1–exposed girl with failure to thrive and diffuse nodular pulmonary infiltrates  Filiz O Seeborg, MD, Mary E Paul, MD, Stuart L Abramson, MD, PhD, Debra L Kearney, MD, Scott R Dorfman, MD, Steven M Holland, MD, William T Shearer, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 113, Issue 4, Pages 627-634 (April 2004) DOI: 10.1016/j.jaci.2004.01.763

Fig 1 A, Pretreatment CT scan demonstrating multiple nodular opacities throughout both lung fields. B, CT scan showing improvement of nodular lung lesions 4 weeks after initiation of antifungal therapy. Journal of Allergy and Clinical Immunology 2004 113, 627-634DOI: (10.1016/j.jaci.2004.01.763)

Fig 2 A, Lung specimen showing granulomatous inflammation consisting of epithelioid histiocytes and multinucleated giant cells (hematoxylin-eosin stain, arrows). B, Methenamine silver stain of the granuloma demonstrating rare and degenerating fungal hyphae (arrows). Journal of Allergy and Clinical Immunology 2004 113, 627-634DOI: (10.1016/j.jaci.2004.01.763)

Fig 3 Immunoblot analysis of neutrophil lysates probed for each of the 4 structural components of the NADPH oxidase complex demonstrating deficiency of the p47phox component, courtesy of Dr Douglas B. Kuhns, Science Applications International Corporation, Frederick, Md. Journal of Allergy and Clinical Immunology 2004 113, 627-634DOI: (10.1016/j.jaci.2004.01.763)