Studies of hypoxemic/reoxygenation injury: Without aortic clamping

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Studies of hypoxemic/reoxygenation injury: Without aortic clamping Kiyozo Morita, MDa, Kai Ihnken, MDa, Gerald D. Buckberg, MDa, Georg Matheis, MDa, Michael P. Sherman, MDb, Helen H. Young, PhDa The Journal of Thoracic and Cardiovascular Surgery Volume 110, Issue 4, Pages 1228-1234 (October 1995) DOI: 10.1016/S0022-5223(95)70009-9 Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 1 LV contractility. LV Ees after discontinuation of CPB, expressed as percent of individual prehypoxemic values. CPB: piglets undergoing CPB without hypoxemia; no treatment: piglets undergoing reoxygenation without treatment; Glu/Asp: piglets undergoing reoxygenation on CPB with glutamate/aspartate supplementation. *p < 0.05 vs no treatment; †p < 0.05 CPB. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1228-1234DOI: (10.1016/S0022-5223(95)70009-9) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 2 Conjugated diene content. Biopsy specimen of LV subendocardial muscle taken 30 minutes after discontinuation of CPB. Dotted bar shows range of values ± SE (A223/ mg total lipid from normoxemic instrumented control piglets. CPB: piglets undergoing CPB without hypoxemia, no treatment: piglets undergoing reoxygenation without treatment; Glu/Asp: piglets undergoing reoxygenation on CPB with glutamate/aspartate supplementation. *p < 0.005 vs no treatment; †p < 0.05 CPB. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1228-1234DOI: (10.1016/S0022-5223(95)70009-9) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 3 Antioxidant reserve capacity. Vulnerability of hypoxemic reoxygenated myocardium to subsequent oxidant stress is determined by exposing tissue to 0 to 4 mmol/L t-butylhydroperoxide for 30 minutes at 37° C with subsequent measurement of thiobuteric acid-reactive substances. MDA, Malondialdehyde; CPB; piglets undergoing CPB without preceding hypoxemia; no treatment: piglets undergoing reoxygenation without treatment, Glu/Asp: piglets undergoing reoxygenation on CPB with glutamate/aspartate supplementation. *p < 0.05 vs no treatment; †p < 0.05 CPB, control. t-BHP, t-butylhydroperoxide. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1228-1234DOI: (10.1016/S0022-5223(95)70009-9) Copyright © 1995 Mosby, Inc. Terms and Conditions