Reversible pulmonary trunk banding

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Max B. Mitchell, MD The Journal of Thoracic and Cardiovascular Surgery

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Presentation transcript:

Reversible pulmonary trunk banding Reversible pulmonary trunk banding. VI: Glucose-6-phosphate dehydrogenase activity in rapid ventricular hypertrophy in young goats Renato S. Assad, MD, PhD, Fernando A. Atik, MD, Fernanda S. Oliveira, Miriam H. Fonseca-Alaniz, BPh, PhD, Maria C.D. Abduch, VMD, PhD, Gustavo J.J. Silva, PE, PhD, Gustavo G. Favaro, MD, Jose E. Krieger, MD, PhD, Noedir A.G. Stolf, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 142, Issue 5, Pages 1108-1113.e1 (November 2011) DOI: 10.1016/j.jtcvs.2011.08.007 Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 A, RV-PA gradient (mm Hg) temporal pattern of sham, continuous, and intermittent groups. B, According to variations in RV-PA gradients in relation to time, the area under the curve (mm Hg h) was calculated to determine the systolic overload imposed on each group. RV, Right ventricle; PA, pulmonary artery. ∗P < .001 compared with that of the sham group. #P < .001 compared with the intermittent group. The Journal of Thoracic and Cardiovascular Surgery 2011 142, 1108-1113.e1DOI: (10.1016/j.jtcvs.2011.08.007) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 RV myocardial performance index during the 96-hour protocol in sham, continuous, and intermittent groups. RV, Right ventricle. ¤P < .04 compared with that in the sham group at the same time. #P < .001 compared with that in the intermittent group at the same time. The Journal of Thoracic and Cardiovascular Surgery 2011 142, 1108-1113.e1DOI: (10.1016/j.jtcvs.2011.08.007) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 RV, ventricular septum, and LV weights in the 3 groups, indexed to body weight. Values (g/kg) = mean ± standard deviation. RV, Right ventricle; LV, left ventricle. ∗P < .05 compared with that in the sham group. The Journal of Thoracic and Cardiovascular Surgery 2011 142, 1108-1113.e1DOI: (10.1016/j.jtcvs.2011.08.007) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 RV/LV ratio of G6PD activity in the sham, continuous, and intermittent groups. Values = mean ± standard deviation. Sham: n = 5; continuous: n = 5; intermittent: n = 10. RV, Right ventricle; LV, left ventricle; G6PD, glucose 6-phosphate dehydrogenase. ∗P < .05 compared with that in the sham and intermittent groups. The Journal of Thoracic and Cardiovascular Surgery 2011 142, 1108-1113.e1DOI: (10.1016/j.jtcvs.2011.08.007) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Figure E1 Pulmonary trunk adjustable banding device used in the protocol, manufactured by SILIMED, Silicone e Instrumental Médico-Cirúrgico e Hospitalar Ltda, Rio de Janeiro, Brazil. The Journal of Thoracic and Cardiovascular Surgery 2011 142, 1108-1113.e1DOI: (10.1016/j.jtcvs.2011.08.007) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Figure E2 RV/aorta systolic pressure ratio of sham, continuous, and intermittent groups, throughout the protocol. RV, Right ventricle. ∗P < .05 compared with its respective baseline and with that in the sham group at the same time. The Journal of Thoracic and Cardiovascular Surgery 2011 142, 1108-1113.e1DOI: (10.1016/j.jtcvs.2011.08.007) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Figure E3 Δ% changes of RV wall thickness of sham, continuous, and intermittent groups throughout the protocol. RV, Right ventricle. ∗P < .001 compared with the respective baseline value. #P < .001 compared with the sham group at the same time. ++P < .02 compared with the continuous group at the same time. The Journal of Thoracic and Cardiovascular Surgery 2011 142, 1108-1113.e1DOI: (10.1016/j.jtcvs.2011.08.007) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Figure E4 Δ% changes of RV end-diastolic volume of sham, continuous, and intermittent groups throughout the protocol. RV, Right ventricle. ∗P < .001 compared with the respective baseline value. #P < .001 compared with the sham group at the same time. The Journal of Thoracic and Cardiovascular Surgery 2011 142, 1108-1113.e1DOI: (10.1016/j.jtcvs.2011.08.007) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions