Whole genome sequencing options for bacterial strain typing and epidemiologic analysis based on single nucleotide polymorphism versus gene-by-gene–based.

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Whole genome sequencing options for bacterial strain typing and epidemiologic analysis based on single nucleotide polymorphism versus gene-by-gene–based approaches A.C. Schürch, S. Arredondo-Alonso, R.J.L. Willems, R.V. Goering Clinical Microbiology and Infection Volume 24, Issue 4, Pages 350-354 (April 2018) DOI: 10.1016/j.cmi.2017.12.016 Copyright © 2018 The Authors Terms and Conditions

Fig. 1 Hypothetical dendrogram (neighbour-joining tree). Interpretation of whole genome sequencing results for epidemiologic investigations should rely on both genetic distance/difference (single nucleotide polymorphisms or alleles) and the topology of the dendrogram/phylogeny to draw conclusions about relatedness. Although a similarity threshold can act as a guide to identify clusters of potentially related isolates (e.g. within boxed area), isolates beyond the threshold but topologically nearby deserve further scrutiny for potential relatedness. Clinical Microbiology and Infection 2018 24, 350-354DOI: (10.1016/j.cmi.2017.12.016) Copyright © 2018 The Authors Terms and Conditions